Structure of PDB 6r4x Chain B Binding Site BS01

Receptor Information

>6r4x Chain B (length=192) Species: 1496 (Clostridioides difficile) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TTIQQNKDTLSQIVVFPTGNYDKNEANAMVNRLANIDGKYLNALKQNNLK
IKLLSGKLTDEKEYAYLKGVVPKGWEGTGKTWDDVPGLGGSTVALRIGFS
NKGKGHDAINLELHATAHAIDHIVLNDISKSAQFKQIFAKEGRSLGNVNF
LGVYPEEFFAESFAYYYLNQDTNSKLKSACPQTYSFLQNLAK

Ligand information

>6r4x Chain C (length=7) Species: 1496 (Clostridioides difficile) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EVNPAVP

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6r4x Molecular determinants of the mechanism and substrate specificity ofClostridium difficileproline-proline endopeptidase-1.
Resolution	1.831 Å
Binding residue (original residue number in PDB)	P100 K101 W103 W110 G115 L116 G117 S119 H134 D135 A136 H142 H146 H150 F178
Binding residue (residue number reindexed from 1)	P72 K73 W75 W82 G87 L88 G89 S91 H106 D107 A108 H114 H118 H122 F150

Enzymatic activity

Enzyme Commision number

3.4.24.89: Pro-Pro endopeptidase.

Gene Ontology

	Molecular Function
GO:0008237	metallopeptidase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0005576	extracellular region

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External links

PDB	RCSB:6r4x, PDBe:6r4x, PDBj:6r4x
PDBsum	6r4x
PubMed	31182482
UniProt	Q183R7\|PPEP1_CLOD6 Pro-Pro endopeptidase (Gene Name=zmp1)

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