Structure of PDB 6qzw Chain B Binding Site BS01

Receptor Information
>6qzw Chain B (length=833) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LEPFYVERYSWSQLKKLLADTRKYHKAPHDFMFVKRNDPDGPHSDRIYYL
AMSRENTLFYSEIPKTINRAAVLMLSWKPLLDLYSREEELLRERKRIGTV
GIASYDYHQGSGTFLFQAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNI
RMDPKLCPADPDWIAFIHSNDIWISNIVTREERRLTYVHNELANMEEDAR
SAGVATFVLQEEFDRYSGYWWCPKAETTPSGGKILRILYEENDESEVEII
HVTSPMLETRRADSFRYPKTGTANPKVTFKMSEIMIDAEGRIIDVIDKEL
IQPFEILFEGVEYIARAGWTPEGKYAWSILLDRSQTRLQIVLISPELFIP
VEDDVMERQRLIESVPDSVTPLIIYEETTDIWINIHDIFHVFPQSHEEEI
EFIFASECKTGFRHLYKITSILKESKYKRSSGGLPAPSDFKCPIKEEIAI
TSGEWEVLGRHGSNIQVDEVRRLVYFEGTKDSPLEHHLYVVSYVNPGEVT
RLTDRGYSHSCCISQHCDFFISKYSNQKNPHCVSLYKLSSPEDDPTCKTK
EFWATILDSAGPLPDYTPPEIFSFESTTGFTLYGMLYKPHDLQPGKKYPT
VLFIYGGPQVQLVNNRFKGVKYFRLNTLASLGYVVVVIDNRGSCHRGLKF
EGAFKYKMGQIEIDDQVEGLQYLASRYDFIDLDRVGIHGWSYGGYLSLMA
LMQRSDIFRVAIAGAPVTLWIFYDTGYTERYMGHPDQNEQGYYLGSVAMQ
AEKFPSEPNRLLLLHGFLDENVHFAHTSILLSFLVRAGKPYDLQIYPQER
HSIRVPESGEHYELHLLHYLQENLGSRIAALKV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6qzw Dipeptidyl peptidase 9 triggers BRCA2 degradation by the N-degron pathway to promote DNA-damage repair
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E275 E276 Y669 S755 Y787 Y791 N835
Binding residue
(residue number reindexed from 1)		E211 E212 Y605 S691 Y723 Y727 N771
Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833 H865
Catalytic site (residue number reindexed from 1) Y605 S691 Y692 D769 H801
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qzw, PDBe:6qzw, PDBj:6qzw
PDBsum6qzw
PubMed
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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