Structure of PDB 6qx8 Chain B Binding Site BS01

Receptor Information

>6qx8 Chain B (length=611) Species: 384505 (Influenza A virus (A/nt/60/1968(H3N2)))

MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMRVNKRSYLIRALTLNTMTKDA
ERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKKAK
LANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQPE
WFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLKYF
NESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQKRY
TKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSKKK
SYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTVIK
NNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKLWE
QTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLNPF
VTTHSWIPKRN

Ligand information

>6qx8 Chain D (length=12)

agcaaaagcagg

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Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qx8 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
• Resolution: 4.07 Å
• Binding residue (original residue number in PDB): H32 G33 T34 Y38 K237 M356 K363 R365
• Binding residue (residue number reindexed from 1): H32 G33 T34 Y38 K206 M325 K332 R334

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0034062 5'-3' RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019083 viral transcription
• GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
• GO:0039694 viral RNA genome replication

Cellular Component

• GO:0030430 host cell cytoplasm
• GO:0042025 host cell nucleus

External links

• PDB: RCSB:6qx8, PDBe:6qx8, PDBj:6qx8
• PDBsum: 6qx8
• PubMed: 31485076
• UniProt: P03432|RDRP_I68A6 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)