Structure of PDB 6qx3 Chain B Binding Site BS01

Receptor Information
>6qx3 Chain B (length=615) Species: 506350 (Influenza A virus (A/Hong Kong/1/1968(H3N2))) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MDVNPTLLFLKVPAQNAISTTFPYTGDPPYSHGTGTGYTMDTVNRTHQYS
EKGKWTTNTETGAPQLNPIDGPLPEDNEPSGYAQTDCVLEAMAFLEESHP
GIFENSCLETMEVVQQTRVDRLTQGRQTYDWTLNRNQPAATALANTIEVF
RSNGLTANESGRLIDFLKDVMESMDKEEMEIRVNKRSYLIRALTLNTMTK
DAERGKLKRRAIATPGMQIRGFVYFVETLARSICEKLEQSGLPVGGNEKK
AKLANVVRKMMTNSQDTELSFTITGDNTKWNENQNPRMFLAMITYITKNQ
PEWFRNVLSIAPIMFSNKMARLGKGYMFESKSMKLRTQIPAEMLASIDLK
YFNESTRKKIEKIRPLLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQK
RYTKTTYWWDGLQSSDDFALIVNAPNHEGIQAGVDRFYRTCKLVGINMSK
KKSYINRTGTFEFTSFFYRYGFVANFSMELPSFGVSGINESADMSIGVTV
IKNNMINNDLGPATAQMALQLFIKDYRYTYRCHRGDTQIQTRRSFELKKL
WEQTRSKAGLLVSDGGPNLYNIRNLHIPEVCLKWELMDEDYQGRLCNPLN
PFVTTHSWIPKRNRS
Ligand information
Receptor-Ligand Complex Structure
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PDB6qx3 Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Resolution3.79 Å
Binding residue
(original residue number in PDB)		H32 G33 T34 M356 R365
Binding residue
(residue number reindexed from 1)		H32 G33 T34 M327 R336
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003968 RNA-dependent RNA polymerase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039523 symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity
GO:0039694 viral RNA genome replication
Cellular Component
GO:0030430 host cell cytoplasm
GO:0042025 host cell nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qx3, PDBe:6qx3, PDBj:6qx3
PDBsum6qx3
PubMed31485076
UniProtQ910D6|RDRP_I68A4 RNA-directed RNA polymerase catalytic subunit (Gene Name=PB1)

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