Structure of PDB 6qs1 Chain B Binding Site BS01

Receptor Information

>6qs1 Chain B (length=603) Species: 9606 (Homo sapiens)

LDPGLQPGQFSADEAGAQLFAQSYQSSAEQVLFQSVAASWAHDTNITAEN
ARRQEEAALLSQEFAEAWGQKAKELYEPIWQQFTDPQLRRIIGAVRTLGS
ANLPLAKRQQYNALLSQMSRIYSTAKVCLTCWSLDPDLTNILASSRSYAM
LLFAWEGWHNAAGIPLKPLYEDFTALSNEAYKQDGFTDTGAYWRSWYNSP
TFEDDLEHLYQQLEPLYLNLHAFVRRALHRRYGDRYINLRGPIPAHLLGD
MWAQSWENIYDMVVPFPDKPNLDVTSTMLQQGWQATHMFRVAEEFFTSLE
LSPMPPEFWEGSMLEKPADGREVVCHASAWDFYNRKDFRIKQCTRVTMDQ
LSTVHHEMGHIQYYLQYKDLPVSLRRGANPGFHEAIGDVLALSVSTPEHL
HKIGLLDRVTNDTESDINYLLKMALEKIAFLPFGYLVDQWRWGVFSGRTP
PSRYNFDWWYLRTKYQGICPPVTRNETHFDAGAKFHVPNVTPYIRYFVSF
VLQFQFHEALCKEAGYEGPLHQCDIYRSTKAGAKLRKVLRAGSSRPWQEV
LKDMVGLDALDAQPLLKYFQLVTQWLQEQNQQNGEVLGWPEYQWHPPLPD
NYP

Ligand information

>6qs1 Chain F (length=5) Species: 242054 (Gloydius blomhoffii)

PKIPP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qs1 Structural basis for the C-domain-selective angiotensin-converting enzyme inhibition by bradykinin-potentiating peptide b (BPPb).
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): Q259 H331 A332 S333 A334 W335 H361 E362 H365 Y369 E389 F435 K489 F490 H491 Y498 Y501
• Binding residue (residue number reindexed from 1): Q254 H326 A327 S328 A329 W330 H356 E357 H360 Y364 E384 F430 K484 F485 H486 Y493 Y496

Enzymatic activity

• Catalytic site (original residue number in PDB): H331 A332 H361 E362 H365 E389 H491 Y501
• Catalytic site (residue number reindexed from 1): H326 A327 H356 E357 H360 E384 H486 Y496
• Enzyme Commision number: 3.4.15.1: peptidyl-dipeptidase A.

Gene Ontology

Molecular Function

• GO:0008237 metallopeptidase activity
• GO:0008241 peptidyl-dipeptidase activity

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:6qs1, PDBe:6qs1, PDBj:6qs1
• PDBsum: 6qs1
• PubMed: 31072910
• UniProt: P12821|ACE_HUMAN Angiotensin-converting enzyme (Gene Name=ACE)