Structure of PDB 6qrm Chain B Binding Site BS01
Receptor Information
>6qrm Chain B (length=391) Species:
9606
(Homo sapiens) [
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PAKTMEEASKRSYQFWDTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQ
GFTWDALDLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPP
GWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEKKMVEINFLCVHKKL
RSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPR
KLIEVKFSHLSNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTR
YLKQFHLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPS
TIMNHPTHKSLKAAYSFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDL
MENKTFLEKLKFGIGDGNLQYYLYNWKCPSMGAEKVGLVLQ
Ligand information
>6qrm Chain D (length=9) Species:
9606
(Homo sapiens) [
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GNCFSKRRA
Receptor-Ligand Complex Structure
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PDB
6qrm
High-resolution snapshots of human N-myristoyltransferase in action illuminate a mechanism promoting N-terminal Lys and Gly myristoylation.
Resolution
2.3 Å
Binding residue
(original residue number in PDB)
V181 E182 D183 F188 R189 F190 N246 T282 R295 Y296 H298 S405 I469 G470 D471 G472 N473 Q496
Binding residue
(residue number reindexed from 1)
V77 E78 D79 F84 R85 F86 N142 T178 R191 Y192 H194 S300 I364 G365 D366 G367 N368 Q391
Enzymatic activity
Enzyme Commision number
2.3.1.-
2.3.1.97
: glycylpeptide N-tetradecanoyltransferase.
Gene Ontology
Molecular Function
GO:0004379
glycylpeptide N-tetradecanoyltransferase activity
Biological Process
GO:0006499
N-terminal protein myristoylation
View graph for
Molecular Function
View graph for
Biological Process
External links
PDB
RCSB:6qrm
,
PDBe:6qrm
,
PDBj:6qrm
PDBsum
6qrm
PubMed
32111831
UniProt
P30419
|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)
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