Structure of PDB 6qp7 Chain B Binding Site BS01

Receptor Information
>6qp7 Chain B (length=619) Species: 7227 (Drosophila melanogaster) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NFYYERPCCTDHVREFNCGKLYYRTFHMNEDRDTLYVGAMDRVFRVNLQN
ISSSNCNRDVINLEPTRDDVVSCVSKGKSQIFDCKNHVRVIQSMDQGDRL
YVCGTNAHNPKDYVIYANLTYLPRSEYVIGVGLGIAKCPYDPLDNSTAIY
VENGNPGGLPGLYSGTNAEFTKADTVIFRTDLYNTSAKRLEYKFKRTLKY
DSKWLDKPNFVGSFDIGEYVYFFFRETAVEYINCGKAVYSRIARVCKKDV
GGKNLLAHNWATYLKARLNCSISGEFPFYFNEIQSVYQLPSDKSRFFATF
TTSTNGLIGSAVCSFHINEIQAAFNGKFKEQSSSNSAWLPVLNSRVPEPR
PGTCVNDTSNLPDTVLNFIRSHPLMDKAVNHEHNNPVYYKRDLVFTKLVV
DKIRIDILNQEYIVYYVGTNLGRIYKIVQYYRNGESLSKLLDIFEVAPNE
AIQVMEISQTRKSLYIGTDHRIKQIDLAMCNRRYDNCFRCVRDPYCGWDK
EANTCRPYELDLLQDVANETSDICDSSVLKKKIVVTYGQSVHLGCFVKIP
EVLKNEQVTWYHHSKDKGRYEIRYSPTKYIETTERGLVVVSVNEADGGRY
DCHLGGSLLCSYNITVDAH
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain6qp7 Chain F Residue 5 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6qp7 Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning.
Resolution1.96 Å
Binding residue
(original residue number in PDB)		K252 K281
Binding residue
(residue number reindexed from 1)		K207 K236
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0030215 semaphorin receptor binding
GO:0045499 chemorepellent activity
Biological Process
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007629 flight behavior
GO:0007632 visual behavior
GO:0016201 synaptic target inhibition
GO:0030154 cell differentiation
GO:0030335 positive regulation of cell migration
GO:0030534 adult behavior
GO:0042756 drinking behavior
GO:0050919 negative chemotaxis
GO:0070983 dendrite guidance
GO:0071526 semaphorin-plexin signaling pathway
GO:0071678 olfactory bulb axon guidance
GO:0097374 sensory neuron axon guidance
Cellular Component
GO:0005576 extracellular region
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0012505 endomembrane system

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6qp7, PDBe:6qp7, PDBj:6qp7
PDBsum6qp7
PubMed31417095
UniProtQ24323|SEM2A_DROME Semaphorin-2A (Gene Name=Sema2a)

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