Structure of PDB 6qkl Chain B Binding Site BS01

Receptor Information

>6qkl Chain B (length=185) Species: 44689 (Dictyostelium discoideum)

MKVINSSRKVQIPENVTVDVKGRSVKVTGPRGTLSKSFDHASVDINLVGK
KELTVDLWFGNRKQIACIKTITSIIENMITGVTKGYEYKMRFVYAHFPIN
VAVTDGGRVVEIRNFFGEKIVRRIELLDGITCYRNEKAKDEIVLTGNSLE
LLSQSCATIQLRSAIKYKDVRKFLDGIYVSERNVL

Ligand information

>6qkl Chain N (length=1158)

auuagcaguuucgggggcguaaugcucucagcugauucucaaacucugaa
cauuuuugguaagcagaacuggcgauguggguugaaccaaauauugggau
aagacgucuaacauucacuaauagauaccacaaaagguguuaguucauua
agacagcaggacgguggccauggaagucgguauccgcuaaggagugugua
acaacucaccugccaaauggacuagcccugaaaauggaugacgcuagcag
uggauggucgaugcccaaucguuaaaagaagugauaauacuuuuaacaau
ccaacuguuuaauuaaaacaaagcauugcgauaagcuuaaaagcuuuuga
cgcaaugugauuucugcccagugcucugaaugucaaagugaagagauuca
accuagcacggguaaacggcgggaguaacuaugacucucuuaagguagcc
aaaugccucgucaucuaauuagugacgcgcaugaauggaucaaugagauu
cccacugucccuaacuacuauacagcgaaaccacugcaaggggaacgggc
cuugcaaaaacagcggggaaagaagacccuguugagcuugacucuagucu
gauauuacaguuucagguggggaguuuggcuggggcggcacauuuguuaa
aagauaacgcaaguguccaaaggcaggcucagugagaacagaaaucucac
guagaguaaaagggcaaaagccugcuugauucugauuuucaguacuaauc
ggaacugggaaaccagggccuaucgauccuuuaugugcuuaaaucuuaac
ccuagaggugucagaaaaguuaccacagggauaacuggcuuguggcagcc
aagcgcucauagcgacgcugcuuuuugauccuucgaugucggcucuucuu
aucauugugaagcagaauucacaaaguguuggauuguucacccacuaaca
aggaacgugagcuggguuuagaccgucgugagacagguuaguuuuacccu
acuguugucaguuugcguaauaguagcaugauuuaguacgagaggaacug
ucaugccggaucacuggucuguagguuuauuugacaaaauagugaccugc
cgcuaccauccguuggauaauggcugaacgccucuaagucagaauccauu
cuagaaac

.....<<<<...<<<<<<.....>>>>>>.>>>>................
<<.<<<<<.....>>>>>.>>......<<<......>>>...<<<<<<..
..<<<(((...<<<<<<<....<<..........<<<.<<<<<<<<<<..
.....<<<<<.<<...<<<.........>>>...>>.........<<...
...>>...>>>>>...>>>>>>>>>>>>>..........))).>>....>
>>>>>>>>>....>>>>>>.<<<<<<<<...........>>>>>>>><<<
<<<..<<<.........>>>..<<<<<<<....<<<<....>>>>.....
.>>>>>>>...<<..<<<..<<<<<.....<<<....<<<<<....>>>>
.>...>>>..>>>..>>>>><<<<<<.......>>>>>>........<..
.........<<<<<.......>>>>>.....>.....>>....>>.>>>>
....................................<<<<<........>
>>>>....<<<<<..<<<.<<......<<<<.<<<<<<..<<<<<.<<<<
<<.<<....>>.>>>>>>..>>>>>...<<<.....>>>..<<<<<<...
........>>>>>>..<<...<<<<<<<...<<<<<<.......>>>>>>
.....<<...(((>>....>>>>>>>...<<<<<<<<.........>>>>
>>>>.<<<....>>>.>>))).......<<<<<...<.<<.......>>.
>.>>>>>..........>>>>..>>>>>>.......<<.<.<.<<<<<<.
..<<.......>>...>>>>>>...>>.>.>.......<<<<<.<<<<<<
..<<<<<<<<<......>>>>>>..>>>.<<<.<.....>.>>>.....>
>>>>..>...>>>.>>....<<<<<<<....>>>.>>>>....>>..>>>
.>>>>>..........<<..<<<..<<<<<<<.................>
>>>>>><<<<<...<<<<....<<<<<<<<<<....>>>>>..>>>>>..
.>>>>..>>>>>.<<<<...<<<<<...........>>>>>...>>>>..
>>>...>>

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6qkl Mechanism of eIF6 release from the nascent 60S ribosomal subunit.
• Resolution: 3.3 Å
• Binding residue (original residue number in PDB): M1 H40 R62 K63 A66 K69 T70 S73 H96 F97 F116 E118 K119 I120 E150 S153 Q154 A157 L161 K166 Y167 K168 D169 R171 K172
• Binding residue (residue number reindexed from 1): M1 H40 R62 K63 A66 K69 T70 S73 H96 F97 F116 E118 K119 I120 E150 S153 Q154 A157 L161 K166 Y167 K168 D169 R171 K172

Gene Ontology

Molecular Function

• GO:0003735 structural constituent of ribosome
• GO:0019843 rRNA binding

Biological Process

• GO:0002181 cytoplasmic translation
• GO:0006412 translation

Cellular Component

• GO:0005840 ribosome
• GO:0022625 cytosolic large ribosomal subunit
• GO:0031012 extracellular matrix
• GO:0045335 phagocytic vesicle
• GO:1990904 ribonucleoprotein complex

External links

• PDB: RCSB:6qkl, PDBe:6qkl, PDBj:6qkl
• PDBsum: 6qkl
• PubMed: 26479198
• UniProt: Q54XI5|RL9_DICDI Large ribosomal subunit protein uL6 (Gene Name=rpl9)