Structure of PDB 6q0w Chain B Binding Site BS01

Receptor Information
>6q0w Chain B (length=208) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
REHVLKQLERVKISGQLSPRLFRKLPPRVCVSLKNIVDEDFLYAGHIFLG
FSKCGRYVLSYTSSSSFYIYHLYWWEFNVHSKLKLVRQVRLFQDEEIYSD
LYLTVCEWPSDASKVIVFGFNTRSANMMSDENHRDIYVSTVAVPPPGRCA
ACQDASNAQCLRHGFMLHTKYQVVYPFPTFQPAFQLKKDQVVLLNTSYSL
VACAVSVH
Ligand information
Ligand IDEF6
InChIInChI=1S/C14H12ClN3O4S2/c15-12-8-17-14-11(12)2-1-3-13(14)18-24(21,22)10-6-4-9(5-7-10)23(16,19)20/h1-8,17-18H,(H2,16,19,20)
InChIKeySETFNECMODOHTO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7c1cc2c(c[nH]c2c(c1)NS(=O)(=O)c3ccc(cc3)S(=O)(=O)N)Cl
CACTVS 3.385N[S](=O)(=O)c1ccc(cc1)[S](=O)(=O)Nc2cccc3c(Cl)c[nH]c23
ACDLabs 12.01N(S(=O)(c1ccc(cc1)S(N)(=O)=O)=O)c2cccc3c2ncc3Cl
FormulaC14 H12 Cl N3 O4 S2
NameN~1~-(3-chloro-1H-indol-7-yl)benzene-1,4-disulfonamide;
Indisulam
ChEMBLCHEMBL77517
DrugBankDB06370
ZINCZINC000000600748
PDB chain6q0w Chain B Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6q0w Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		T230 F231 Q232 P233 A234 F235
Binding residue
(residue number reindexed from 1)		T179 F180 Q181 P182 A183 F184
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0016567 protein ubiquitination

View graph for
Biological Process
External links
PDB RCSB:6q0w, PDBe:6q0w, PDBj:6q0w
PDBsum6q0w
PubMed31686031
UniProtQ66K64|DCA15_HUMAN DDB1- and CUL4-associated factor 15 (Gene Name=DCAF15)

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