Structure of PDB 6pxu Chain B Binding Site BS01

Receptor Information
>6pxu Chain B (length=532) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGPPRTPRPGRREPVMPRPPVPANALGARGEAVRLQLQGEELRLQEESVR
LHQINIYLSDRISLHRRLPERWNPLCKEKKYDYDNLPRTSVIIAFYNEAW
STLLRTVYSVLETSPDILLEEVILVDDYSDREHLKERLANELSGLPKVRL
IRANKREGLVRARLLGASAARGDVLTFLDCHCECHEGWLEPLLQRIHEEE
SAVVCPVIDVIDWNTFEYLGNSGEPQIGGFDWRLVFTWHTVPERERIRMQ
SPVDVIRSPTMAGGLFAVSKKYFEYLGSYDTGMEVWGGENLEFSFRIWQC
GGVLETHPCSHVGHVFPKQAPYSRNKALANSVRAAEVWMDEFKELYYHRN
PRARLEPFGDVTERKQLRDKLQCKDFKWFLETVYPELHVPEDRPGFFGML
QNKGLTDYCFDYNPPDENQIVGHQVILYLCHGMGQNQFFEYTSQKEIRYN
THQPEGCIAVEAGMDTLIMHLCEETAPENQKFILQEDGSLFHEQSKKCVQ
AARKESSDSFVPLLRDCTNSDHQKWFFKERML
Ligand information
>6pxu Chain D (length=15) Species: 32630 (synthetic construct) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GAGATGYYITPRTGA
Receptor-Ligand Complex Structure
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PDB6pxu The structure of the colorectal cancer-associated enzyme GalNAc-T12 reveals how nonconserved residues dictate its function.
Resolution2.007 Å
Binding residue
(original residue number in PDB)		F285 W287 W335 F365 R373 M482
Binding residue
(residue number reindexed from 1)		F236 W238 W286 F316 R324 M433
Enzymatic activity
Enzyme Commision number 2.4.1.41: polypeptide N-acetylgalactosaminyltransferase.
Gene Ontology
Molecular Function
GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity
GO:0005515 protein binding
GO:0016757 glycosyltransferase activity
GO:0030246 carbohydrate binding
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0006493 protein O-linked glycosylation
GO:0016266 O-glycan processing
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6pxu, PDBe:6pxu, PDBj:6pxu
PDBsum6pxu
PubMed31548401
UniProtQ8IXK2|GLT12_HUMAN Polypeptide N-acetylgalactosaminyltransferase 12 (Gene Name=GALNT12)

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