Structure of PDB 6pxj Chain B Binding Site BS01

Receptor Information
>6pxj Chain B (length=245) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNSVLQVVN
LPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSP
FNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Ligand information
>6pxj Chain A (length=28) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
EADCGLRPLFEKKSLEDKTERELLESYI
Receptor-Ligand Complex Structure
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PDB6pxj Role of the I16-D194 ionic interaction in the trypsin fold.
Resolution1.7 Å
Binding residue
(original residue number in PDB)		E23 G25 M26 P28 W29 D116 H119 P120 C122 Y134 K135 R137 N159 M201 K202 N205 R206 W207
Binding residue
(residue number reindexed from 1)		E8 G10 M11 P13 W14 D113 H116 P117 C119 Y134 K135 R137 N150 M197 K198 N203 R204 W205
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195
Catalytic site (residue number reindexed from 1) H43 D99 E188 G189 D190 S191
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6pxj, PDBe:6pxj, PDBj:6pxj
PDBsum6pxj
PubMed31792294
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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