Structure of PDB 6pkx Chain B Binding Site BS01

Receptor Information
>6pkx Chain B (length=1218) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LASWIKENIKKKVRETPTDAFGDISFKTGKYVRVSSDTSCENLYQLMTEQ
WKLRSPNLLISVTGKNFYIKTHLKDKFRRGLIKVAQTTGAWILTGGTHAG
VMKHVGMAVRDYTLSSGSMEGQIVVIGVAPWGVIHNRSTLIHPEGRFPAY
YSLDEQGQGRLSCLDINHTHFLLVDDGTQGHYGVEIELRARLEKLISKLS
VTIPVVCVVLDGGPGTLNTIYNSMLNHTPCVVLEGSGRLADVIAHVASVP
VSKVTMALINRLLKRFFMQEYKNFTELQIIEWTKKIQDILRMPHLLTVFR
IDEDKNYDVDVAILQALLKASRSDEHAGRHCWERQLELAVAWNRVDIAES
EIFTEESQWTSSDLHPAMFSALVGDKPEFVRLLLENGVCVREFLEREETL
CELYSHLPSCFFLRKLAKRVQCLSHVSEEVRHLLGSFTQPLYIASRTVWD
PGRDLFLWAVVQNNRELAEIGWEQCRDCIAAALAASKILRKLAQESGEDD
SEEATEMLELANHYEKQAIGVFSECHSWDAQRAQKLLIRISPSWGRSTCL
WLALEAHDKSFIAHSGVQALLTQIWCGELSVDNPHWKVLLCMIFFPLIYT
GFLTFRRDEDIQRQAERTEQQKCSSRLMSFLKSPQVKFYWNIASYFGFLW
LFAVVLMIDFQTSPSWRELLLYVWLTSLVCEEIRQLYHDGFRRKAKMYIK
DLWNILDVLSIVLFIAGLICRLQASDTVFYIGKVILCIDFIIFCLRLMAI
FSISRTLGPKIIIVRRMMLDLFFFMFLLSIWVVAYGVAKQGILIENEERL
NWIIRGAVYEPYITIFGNFPTNIDNTLFDISSCSVNASDPLKPKCPMLNA
DNTPVFPEWLTIMMLCVYLLFANILLLNLLIAIFNYTFQEVQDNTDTIWK
FQRYELIKEYHSRPALPPPFILLSHLILFIRGRHKNFRQELEQTEEEELL
SWEAYMKDNYLASTRQDESQSVEHRIHDTAEKVGAMSELLEREQEMVAAA
AAAAAAAAAAAAAAAAAAAEAPHMFARQLQYPDSTVRRFPVPEEKVSWEV
NFSPYQPPVYNQQDKHRNPGGRTGIRGKGALNTLGPNHILHPIFTRWRDA
EHKVLEFLAVWEDAEKRWALLGGPAQPDLAQVLERILGKKLKTLLKAGEE
VYKGYVDDSRNTDNAWVETSIITLHTPLMADLNHMVESSQPLQWREVSSD
ACRCSYQREALRQIAHHH
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6pkx Chain B Residue 1601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6pkx Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Resolution4.2 Å
Binding residue
(original residue number in PDB)		Q860 N883
Binding residue
(residue number reindexed from 1)		Q685 N704
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005262 calcium channel activity
GO:0005509 calcium ion binding
GO:0046872 metal ion binding
GO:0047631 ADP-ribose diphosphatase activity
GO:0072570 ADP-D-ribose binding
GO:0072571 mono-ADP-D-ribose binding
GO:0099094 ligand-gated monoatomic cation channel activity
GO:0099604 ligand-gated calcium channel activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0019722 calcium-mediated signaling
GO:0051289 protein homotetramerization
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6pkx, PDBe:6pkx, PDBj:6pkx
PDBsum6pkx
PubMed31431622
UniProtA0A0R4IMY7|TRPM2_DANRE Transient receptor potential cation channel subfamily M member 2 (Gene Name=trpm2)

[Back to BioLiP]