Structure of PDB 6ped Chain B Binding Site BS01

Receptor Information
>6ped Chain B (length=126) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YFQGMKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMI
PKVEWSAFLEAADNLRLIQVPKGPVEGYEENEEFLRTMHHLLLEVEVIEG
TLQCPESGRMFPISRGIPNMLLSEEE
Ligand information
Ligand IDSAH
InChIInChI=1S/C14H20N6O5S/c15-6(14(23)24)1-2-26-3-7-9(21)10(22)13(25-7)20-5-19-8-11(16)17-4-18-12(8)20/h4-7,9-10,13,21-22H,1-3,15H2,(H,23,24)(H2,16,17,18)/t6-,7+,9+,10+,13+/m0/s1
InChIKeyZJUKTBDSGOFHSH-WFMPWKQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CCSC[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23)C(O)=O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C(C(O3)CSCCC(C(=O)O)N)O)O)N
CACTVS 3.341N[C@@H](CCSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23)C(O)=O
ACDLabs 10.04O=C(O)C(N)CCSCC3OC(n2cnc1c(ncnc12)N)C(O)C3O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@@H]([C@H](O3)CSCC[C@@H](C(=O)O)N)O)O)N
FormulaC14 H20 N6 O5 S
NameS-ADENOSYL-L-HOMOCYSTEINE
ChEMBLCHEMBL418052
DrugBankDB01752
ZINCZINC000004228232
PDB chain6ped Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6ped Crystal structure of HEMK2-TRMT112 complex
Resolution2.3 Å
Binding residue
(original residue number in PDB)		E120 E121 E122
Binding residue
(residue number reindexed from 1)		E124 E125 E126
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0008276 protein methyltransferase activity
GO:0046982 protein heterodimerization activity
GO:0141106 tRNA methyltransferase activator activity
Biological Process
GO:0006364 rRNA processing
GO:0018364 peptidyl-glutamine methylation
GO:0030488 tRNA methylation
GO:0031167 rRNA methylation
GO:0045815 transcription initiation-coupled chromatin remodeling
GO:0070476 rRNA (guanine-N7)-methylation
GO:2000234 positive regulation of rRNA processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0032991 protein-containing complex
GO:0048471 perinuclear region of cytoplasm

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:6ped, PDBe:6ped, PDBj:6ped
PDBsum6ped
PubMed
UniProtQ9UI30|TR112_HUMAN Multifunctional methyltransferase subunit TRM112-like protein (Gene Name=TRMT112)

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