Structure of PDB 6p40 Chain B Binding Site BS01

Receptor Information
>6p40 Chain B (length=364) Species: 9544 (Macaca mulatta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NMVEPMDPRTFVSNFNNRPILSGLDTVWLCCEVKTKDPSGPPLDAKIFQG
KVYPKAKYHPEMRFLRWFHKWRQLHHDQEYKVTWYVSWSPCTRCANSVAT
FLAKDPKVTLTIFVARLYYYWDPDYQQALRILAEAGATMKIMNYNEFQDC
WNKFVDGRGKPFKPWNNLPSHYTSLQATLGELLRHLMDPGTFTSNFNNKP
WVSGQHETYLCYKVERLHNDTWVPLNQHRGFLRNQAGRHAALCFLDLIPF
WKLDGQQYRVTCFTSWSPCFSCAQEMAKFISNNEHVSLCIFAARIYDDQG
RYQEGLRTLHRDGAKIAMMNYSEFEYCWDTFVDRQGRPFQPWDGLDEHSQ
ALSGRLRAILQNQG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6p40 Chain B Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6p40 Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G.
Resolution2.452 Å
Binding residue
(original residue number in PDB)		H65 C97 C100
Binding residue
(residue number reindexed from 1)		H59 C91 C94
Annotation score1
Enzymatic activity
Enzyme Commision number 3.5.4.-
3.5.4.38: single-stranded DNA cytosine deaminase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:6p40, PDBe:6p40, PDBj:6p40
PDBsum6p40
PubMed32005813
UniProtM1GSK9

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