Structure of PDB 6ou1 Chain B Binding Site BS01

Receptor Information
>6ou1 Chain B (length=255) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GCGELVWVGEPVTLRTAGKYGVWMRDPKPVYPYTQETTWRIDTVGTDVRQ
VFEYDLISQFMQGYPSKVHILPRPLESTGAVVYNGSLYFQGAGSRTVIRY
DLKTETVKAEKEIPGAGYHGQYPYSWGGYTDIDLAVDENGLWVIYSTNQA
KGNIVLSKLNPETLEVEQTWETNIRKQSVANAFIICGTLYTVSSYTSADA
TVNFAYDTNTGTSKYLDIPFKNRYKYNSMIDYNPLERKLFAWDNGHMVTY
DIKLS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain6ou1 Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6ou1 Stable calcium-free myocilin olfactomedin domain variants reveal challenges in differentiating between benign and glaucoma-causing mutations.
Resolution1.878 Å
Binding residue
(original residue number in PDB)		D380 N428 I477 D478
Binding residue
(residue number reindexed from 1)		D133 N181 I230 D231
Annotation score4
Enzymatic activity
Enzyme Commision number ?
External links
PDB RCSB:6ou1, PDBe:6ou1, PDBj:6ou1
PDBsum6ou1
PubMed31270212
UniProtQ99972|MYOC_HUMAN Myocilin (Gene Name=MYOC)

[Back to BioLiP]