Structure of PDB 6or7 Chain B Binding Site BS01

Receptor Information
>6or7 Chain B (length=388) Species: 11706 (HIV-1 M:B_HXB2R) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPY
NTPVFAIKKKTKWRKLVDFRELNKRTQDHPAGLKKKKSVTVLDVGDAYFS
VPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKI
LEPFRKQNPDIVIYQYMDDLYVGSDLEIGQHRTKIEELRQHLLRELHPDK
WTVQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLSKLLRGTKA
LTEVIPLTEEAELELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWT
YQIYQEPFKNLKTGKYARMHTNDVKQLTEAVQKITTESIVIWGKTPKFKL
PIQKETWETWWTEYWQATWIPEWEFVNTPPLVKLWYQL
Ligand information
Receptor-Ligand Complex Structure
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PDB6or7 Structural insights into the recognition of nucleoside reverse transcriptase inhibitors by HIV-1 reverse transcriptase: First crystal structures with reverse transcriptase and the active triphosphate forms of lamivudine and emtricitabine.
Resolution2.53 Å
Binding residue
(original residue number in PDB)		K395 N418
Binding residue
(residue number reindexed from 1)		K354 N377
Enzymatic activity
Enzyme Commision number 2.7.7.-
2.7.7.49: RNA-directed DNA polymerase.
2.7.7.7: DNA-directed DNA polymerase.
3.1.-.-
3.1.13.2: exoribonuclease H.
3.1.26.13: retroviral ribonuclease H.
3.4.23.16: HIV-1 retropepsin.
Gene Ontology
Molecular Function
GO:0003964 RNA-directed DNA polymerase activity
Biological Process
GO:0006278 RNA-templated DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6or7, PDBe:6or7, PDBj:6or7
PDBsum6or7
PubMed31301259
UniProtP04585|POL_HV1H2 Gag-Pol polyprotein (Gene Name=gag-pol)

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