Structure of PDB 6obq Chain B Binding Site BS01

Receptor Information
>6obq Chain B (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELE
APLKICGDIKGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICL
LLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCF
NCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLW
SDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYE
FFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6obq SDS22 selectively recognizes and traps metal-deficient inactive PP1.
Resolution1.84 Å
Binding residue
(original residue number in PDB)		R96 S129 Y134 W206 D220 R221 Y272 C273 G274 E275
Binding residue
(residue number reindexed from 1)		R90 S123 Y128 W200 D214 R215 Y266 C267 G268 E269
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:6obq, PDBe:6obq, PDBj:6obq
PDBsum6obq
PubMed31548429
UniProtP62136|PP1A_HUMAN Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (Gene Name=PPP1CA)

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