Structure of PDB 6oaz Chain B Binding Site BS01
Receptor Information
>6oaz Chain B (length=416) Species:
9606
(Homo sapiens) [
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QRRDFIDIESKFALRTPEDTAEDTCHLIPGVAESVATCHFNHSSKTFMVI
HGWTVTGMYESWVPKLVAALYKREPDSNVIVVDWLSRAQEHYPVSAGYTK
LVGQDVARFINWMEEEFNYPLDNVHLLGYSLGAHAAGIAGSLTNKKVNRI
TGLDPAGPNFEYAEAPSRLSPDDADFVDVLHTFTRGSPGRSIGIQKPVGH
VDIYPNGGTFQPGCNLVKCSHERSIHLFIDSLLNEENPSKAYRCSSKEAF
EKGLCLSCRKNRCNNLGYEINKVRAKRSSKMYLKTRSQMPYKVFHYQVKI
HFSGTESETHTNQAFEISLYGTVAESENIPFTLPEVSTNKTYSFLIYTEV
DIGELLMLKLKWKSWWSSPGFAIQKIRVKAGETQKKVIFCSREKVSHLQK
GKAPAVFVKCHDKSLN
Ligand information
Ligand ID
CA
InChI
InChI=1S/Ca/q+2
InChIKey
BHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
Software
SMILES
CACTVS 3.341
[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Ca+2]
Formula
Ca
Name
CALCIUM ION
ChEMBL
DrugBank
DB14577
ZINC
PDB chain
6oaz Chain B Residue 505 [
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Receptor-Ligand Complex Structure
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PDB
6oaz
Structure of lipoprotein lipase in complex with GPIHBP1.
Resolution
3.04 Å
Binding residue
(original residue number in PDB)
A194 P195 R197 S199 D202
Binding residue
(residue number reindexed from 1)
A165 P166 R168 S170 D173
Annotation score
1
Enzymatic activity
Catalytic site (original residue number in PDB)
W82 S159 L160 D183 H268
Catalytic site (residue number reindexed from 1)
W53 S130 L131 D154 H221
Enzyme Commision number
3.1.1.32
: phospholipase A1.
3.1.1.34
: lipoprotein lipase.
Gene Ontology
Molecular Function
GO:0004465
lipoprotein lipase activity
GO:0004620
phospholipase activity
GO:0004806
triacylglycerol lipase activity
GO:0005102
signaling receptor binding
GO:0005509
calcium ion binding
GO:0005515
protein binding
GO:0008201
heparin binding
GO:0008970
phospholipase A1 activity
GO:0016298
lipase activity
GO:0016787
hydrolase activity
GO:0034185
apolipoprotein binding
GO:0042803
protein homodimerization activity
GO:0043395
heparan sulfate proteoglycan binding
GO:0043495
protein-membrane adaptor activity
GO:0046872
metal ion binding
GO:0052689
carboxylic ester hydrolase activity
GO:0052739
phosphatidylserine 1-acylhydrolase activity
GO:0071813
lipoprotein particle binding
Biological Process
GO:0006629
lipid metabolic process
GO:0006631
fatty acid metabolic process
GO:0006633
fatty acid biosynthetic process
GO:0006641
triglyceride metabolic process
GO:0006644
phospholipid metabolic process
GO:0009617
response to bacterium
GO:0009749
response to glucose
GO:0010744
positive regulation of macrophage derived foam cell differentiation
GO:0010884
positive regulation of lipid storage
GO:0010886
positive regulation of cholesterol storage
GO:0010890
positive regulation of sequestering of triglyceride
GO:0016042
lipid catabolic process
GO:0019433
triglyceride catabolic process
GO:0031670
cellular response to nutrient
GO:0032722
positive regulation of chemokine production
GO:0032731
positive regulation of interleukin-1 beta production
GO:0032755
positive regulation of interleukin-6 production
GO:0032760
positive regulation of tumor necrosis factor production
GO:0034371
chylomicron remodeling
GO:0034372
very-low-density lipoprotein particle remodeling
GO:0034375
high-density lipoprotein particle remodeling
GO:0042632
cholesterol homeostasis
GO:0045600
positive regulation of fat cell differentiation
GO:0050729
positive regulation of inflammatory response
GO:0055096
low-density lipoprotein particle mediated signaling
GO:0070328
triglyceride homeostasis
GO:0071398
cellular response to fatty acid
GO:1904179
positive regulation of adipose tissue development
GO:2000343
positive regulation of chemokine (C-X-C motif) ligand 2 production
Cellular Component
GO:0005576
extracellular region
GO:0005615
extracellular space
GO:0005886
plasma membrane
GO:0009986
cell surface
GO:0034361
very-low-density lipoprotein particle
GO:0042627
chylomicron
GO:1902494
catalytic complex
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:6oaz
,
PDBe:6oaz
,
PDBj:6oaz
PDBsum
6oaz
PubMed
31072929
UniProt
P06858
|LIPL_HUMAN Lipoprotein lipase (Gene Name=LPL)
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