Structure of PDB 6o60 Chain B Binding Site BS01

Receptor Information
>6o60 Chain B (length=320) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDVIIKSDAPDTLLLEKHADYIASYGDDYEYCMSEYLRMSGIYWGLTVMD
LMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTLY
DSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGK
LDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLH
QVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKIIGRLHWI
DREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLGEEQIKP
VNPVFCMPEEVLQRVNVQPE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6o60 Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6o60 GGTase3 is a newly identified geranylgeranyltransferase targeting a ubiquitin ligase.
Resolution2.503 Å
Binding residue
(original residue number in PDB)		D238 C240 H290
Binding residue
(residue number reindexed from 1)		D230 C232 H282
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.60: protein geranylgeranyltransferase type II.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004659 prenyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008318 protein prenyltransferase activity
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0007601 visual perception
GO:0018344 protein geranylgeranylation
GO:0036211 protein modification process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005968 Rab-protein geranylgeranyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6o60, PDBe:6o60, PDBj:6o60
PDBsum6o60
PubMed31209342
UniProtP53611|PGTB2_HUMAN Geranylgeranyl transferase type-2 subunit beta (Gene Name=RABGGTB)

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