Structure of PDB 6o5f Chain B Binding Site BS01

Receptor Information
>6o5f Chain B (length=417) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DDWSKPLPPSERLEQELFKYDDIPVEATGNNCPPHIESFSDVEMGEIIMG
NIELTRYTRPTPVQKHAIPIIKEKRDLMACAQTGSGKTAAFLLPILSQIY
SDGPGEALRAMKQYPISLVLAPTRELAVQIYEEARKFSYRSRVRPCVVYG
GADIGQQIRDLERGCHLLVATPGRLVDMMERGKIGLDFCKYLVLDEADRM
LDMGFEPQIRRIVEQDTMPPKGVRHTMMFSATFPKEIQMLARDFLDEYIF
LAVENITQKVVWVEESDKRSFLLDLLNATGKDSLTLVFVETKKGADSLED
FLYHEGYACTSIHGDRSQRDREEALHQFRSGKSPILVATAVAARSNVKHV
INFDLPSDIEEYVHRIGRTGRVGNLGLATSFFNERNINITKDLLDLLVEA
KQEVPSWLENMAYEHHY
Ligand information
>6o5f Chain C (length=23) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
caaggucauucgcaagaguggcc
.......................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB6o5f The mechanism of RNA duplex recognition and unwinding by DEAD-box helicase DDX3X.
Resolution2.504 Å
Binding residue
(original residue number in PDB)		E180 R199 S520 D521 N551
Binding residue
(residue number reindexed from 1)		E37 R56 S357 D358 N388
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003724 RNA helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:6o5f, PDBe:6o5f, PDBj:6o5f
PDBsum6o5f
PubMed31300642
UniProtO00571|DDX3X_HUMAN ATP-dependent RNA helicase DDX3X (Gene Name=DDX3X)

[Back to BioLiP]