Structure of PDB 6o5c Chain B Binding Site BS01

Receptor Information
>6o5c Chain B (length=204) Species: 301448 (Streptococcus pyogenes serotype M3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EDYLKCIYEIGEQETNKMVAEKMHVSAPAVSEMIKKMISQGWDKAKGYLL
KDKGYALVANLYRKHRLIEVFLIHQLGYNTQEVHQEAEVLEHTVSDTFID
RLDKILDFPDFCPHGGTIPRYGQPLVEMNTTTLNTITELGRFRLSRIHDH
FDLIQYLETHHLNINTELTLTQIDTFAKTYTICYGDKELVIPENIAKQLY
VTAL
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6o5c Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6o5c Metal sensing and regulation of adaptive responses to manganese limitation by MtsR is critical for group A streptococcus virulence.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		E80 C123 H125 D160
Binding residue
(residue number reindexed from 1)		E69 C112 H114 D149
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6o5c, PDBe:6o5c, PDBj:6o5c
PDBsum6o5c
PubMed31188450
UniProtA0A0H2UTK0

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