Structure of PDB 6o16 Chain B Binding Site BS01

Receptor Information

>6o16 Chain B (length=797) Species: 10090 (Mus musculus)

VFIPVNRTPEMQEERLKLPILAEEQAIMEAVAEHPIVIVCGETGSGKTTQ
VPQFLYEAGYSSEDSIIGVTEPRRVAAVAMSQRVAKEMNLSHRVVSYQIR
YEGNVTEETRIKFMTDGVLLKEIQKDFLLLKYKVVIIDEAHERSVYTDIL
LGLLSRIVALRAKRHLPLKLLIMSATLRVEDFTQNQRLFTTPPPVIKVES
FPVTVHFNKRTPLDYSGECFRKVCKIHRMLPAGGILVFLTGQAEVHALCR
RLRKAFPSLPLHVLPLYSLLAPEKQAQVFKPPPRLCVVATNVAETSLTIP
GIKYVVDCGKVKKRYYDRVTGVSSFRVTWVSQASADQRAGRAGRTEPGHC
YRLYSSAVFGDFEQFPPPEITRRPVEDLILQMKALSIEKVINFPFPTPPS
VEALVAAEELLVALGALQAQMSQLSCPITALGRTMSTFPVAPRYAKMLAL
SQQHGCLPYTIAIVAAMTVRELFEELDLAELKGRRARVAQMKRTWAGQGP
SLKLGDLMVLLGAVGACEYAGCSPQFCQANGLRYKAMLEIRRLRGQLTTA
VNAVCPPKMQPPTESQVTYLRQIMAAGLGDHLARRVQSLDPKWKNAYKTP
LLDDPVFIHPSSVLFKELPEFVVYQEIVETTKMYMKGVSTVEIQWIPSLL
PSYCQFDAPLEEPAPSYCPESGQVLCHRASVFYRVGWPLPAVQVDFPEGI
DRYKYFAKFLLEGQVFRKLASFKSCLLSSPSTMLKTWARLQPRTETLLRA
LVAHKADSRDSLLAAWKKNPKYLLAEYCEWLPKAMHSDVEKNWPPTT

Ligand information

>6o16 Chain D (length=10)

uuuuuuuuuu

..........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6o16 Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis.
• Resolution: 2.875 Å
• Binding residue (original residue number in PDB): P302 R303 R304 R330 T345 G347 V348 Y376 G474 Q475 S588 T613 N614 S619 K635 F648 P772 R803 E804 Q887 N946 H960 P961 F966 K967 T981 K983 Y985
• Binding residue (residue number reindexed from 1): P72 R73 R74 R100 T115 G117 V118 Y146 G241 Q242 S268 T290 N291 S296 K312 F325 P439 R470 E471 Q546 N595 H609 P610 F615 K616 T630 K632 Y634
• Binding affinity: PDBbind-CN: Kd=9.83nM

Enzymatic activity

• Enzyme Commision number: 3.6.4.13: RNA helicase.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding
• GO:0005524 ATP binding

External links

• PDB: RCSB:6o16, PDBe:6o16, PDBj:6o16
• PDBsum: 6o16
• PubMed: 30910870
• UniProt: Q6NZL1