Structure of PDB 6nph Chain B Binding Site BS01

Receptor Information
>6nph Chain B (length=472) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KFGWIKGVLVRCMLNIWGVMLFIRMTWIVGQAGIAYSCIIVIMATVVTTI
TGCSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMY
VVGFAETVVELLMDSGLLMIDQTNDIRVIGTITVILLLGISVAGMEWEAK
AQIFLLVILITAIFNYFIGSFIAVDSKKKFGFFSYDAGILAENFGPDFRG
QTFFSVFSIFFPAATGILAGANISGDLADPQMAIPKGTLLAILITGLVYV
GVAISAGACIVRDATGIESNFTLISNCTDAACKYGYDFSSCRPTVEGEVS
SCKFGLHNDFQVMSVVSGFSPLISAGIFSATLSSALASLVSAPKVFQALC
KDNIYPGIAIFGKGYGKNNEPLRGYFLTFGIALAFILIAELNVIAPIISN
FFLASYALINFSVFHASLANSPGWRPSFKYYNMWASLAGAILCCVVMFII
NWWAALLTNVIVLSLYIYVSYK
Ligand information
Ligand IDK
InChIInChI=1S/K/q+1
InChIKeyNPYPAHLBTDXSSS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[K+]
FormulaK
NamePOTASSIUM ION
ChEMBLCHEMBL1233793
DrugBankDB01345
ZINC
PDB chain6nph Chain B Residue 805 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6nph Structure and mechanism of the cation-chloride cotransporter NKCC1.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		N220 I221 G223 Y305 P417 A418 T420
Binding residue
(residue number reindexed from 1)		N15 I16 G18 Y100 P212 A213 T215
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015377 chloride:monoatomic cation symporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0006811 monoatomic ion transport
GO:0055085 transmembrane transport
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6nph, PDBe:6nph, PDBj:6nph
PDBsum6nph
PubMed31367042
UniProtA0A0G2KTI4|S12A2_DANRE Solute carrier family 12 member 2 (Gene Name=slc12a2)

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