Structure of PDB 6nkp Chain B Binding Site BS01
Receptor Information
>6nkp Chain B (length=179) Species:
9606
(Homo sapiens) [
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PGEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSG
DQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAE
SDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTR
KGFYLAFQDIGACVALLSVRVYYKKAHHH
Ligand information
>6nkp Chain D (length=12) Species:
32630
(synthetic construct) [
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AWLAYPDSVPYS
Receptor-Ligand Complex Structure
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PDB
6nkp
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
Resolution
2.033 Å
Binding residue
(original residue number in PDB)
L54 M55 Q56 N57 M59 Y65 M66 C70 R103 F108 P109 F156 R159 V161 C188 V189
Binding residue
(residue number reindexed from 1)
L29 M30 Q31 N32 M34 Y40 M41 C45 R78 F83 P84 F131 R134 V136 C163 V164
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:6nkp
,
PDBe:6nkp
,
PDBj:6nkp
PDBsum
6nkp
PubMed
31015204
UniProt
P29317
|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)
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