Structure of PDB 6njz Chain B Binding Site BS01
Receptor Information
>6njz Chain B (length=180) Species:
9606
(Homo sapiens) [
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PGEVVLLDFAAAGGELGWLTHPYGKGWDLMQNIMNDMPIYMYSVCNVMSG
DQDNWLRTNWVYRGEAERIFIELKFTVRDCNSFPGGASSCKETFNLYYAE
SDLDYGTNFQKRLFTKIDTIAPDEITVSSDFEARHVKLNVEERSVGPLTR
KGFYLAFQDIGACVALLSVRVYYKKAHHHH
Ligand information
>6njz Chain D (length=10) Species:
32630
(synthetic construct) [
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YSAYPDSVPM
Receptor-Ligand Complex Structure
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PDB
6njz
Engineering nanomolar peptide ligands that differentially modulate EphA2 receptor signaling.
Resolution
1.9 Å
Binding residue
(original residue number in PDB)
L54 M55 Q56 N57 M59 Y65 M66 C70 R103 F108 F156 R159 V161 C188 V189 L192
Binding residue
(residue number reindexed from 1)
L29 M30 Q31 N32 M34 Y40 M41 C45 R78 F83 F131 R134 V136 C163 V164 L167
Enzymatic activity
Enzyme Commision number
2.7.10.1
: receptor protein-tyrosine kinase.
External links
PDB
RCSB:6njz
,
PDBe:6njz
,
PDBj:6njz
PDBsum
6njz
PubMed
31015204
UniProt
P29317
|EPHA2_HUMAN Ephrin type-A receptor 2 (Gene Name=EPHA2)
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