Structure of PDB 6ni2 Chain B Binding Site BS01

Receptor Information
>6ni2 Chain B (length=353) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TRVFKKASPNGKLTVYLGKRDFVDHIDLVEPVDGVVLVDPEYLKERRVYV
TLTCAFRYGREDLDVLGLTFRKDLFVANVQSFPPAPEDKKPLTRLQERLI
KKLGEHAYPFTFEIPPNLPCSVTLQPGPEDTGKACGVDYEVKAFCAENLE
EKIHKRNSVRLVIRKVQYAPERPGPQPTAETTRQFLMSDKPLHLEASLDK
EIYYHGEPISVNVHVTNNTNKTVKKIKISVRQYADICLFNTAQYKCPVAM
EEADDTVAPSSTFCKVYTLTPFLANNREKRGLALDGKLKHEDTNLASSTL
LREREILGIIVSYKVKVKLVVSRGGLLGDLASSDVAVELPFTLMHPKPKE
EPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ni2 Structure of an endosomal signaling GPCR-G protein-beta-arrestin megacomplex.
Resolution4.0 Å
Binding residue
(original residue number in PDB)		T6 R7 V8 K10 K11 Y21 R103 K107 K294
Binding residue
(residue number reindexed from 1)		T1 R2 V3 K5 K6 Y16 R98 K102 K289
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000822 inositol hexakisphosphate binding
GO:0001664 G protein-coupled receptor binding
GO:0005515 protein binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0030276 clathrin binding
GO:0032050 clathrin heavy chain binding
GO:0033130 acetylcholine receptor binding
GO:0035612 AP-2 adaptor complex binding
GO:0036094 small molecule binding
GO:0060090 molecular adaptor activity
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002029 desensitization of G protein-coupled receptor signaling pathway
GO:0002031 G protein-coupled receptor internalization
GO:0002092 positive regulation of receptor internalization
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0009968 negative regulation of signal transduction
GO:0015031 protein transport
GO:0031623 receptor internalization
GO:0045746 negative regulation of Notch signaling pathway
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0072583 clathrin-dependent endocytosis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005905 clathrin-coated pit
GO:0030132 clathrin coat of coated pit
GO:0031143 pseudopodium
GO:0031410 cytoplasmic vesicle
GO:0042995 cell projection

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6ni2, PDBe:6ni2, PDBj:6ni2
PDBsum6ni2
PubMed31740855
UniProtP17870|ARRB1_BOVIN Beta-arrestin-1 (Gene Name=ARRB1)

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