Structure of PDB 6n53 Chain B Binding Site BS01

Receptor Information

>6n53 Chain B (length=211) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GEPFLIGVSGGTASGKSSVCAKIVQLLGQNEVQKQVVILSQDSFYRVLTS
EQKAKALKGQFNFDHPDAFDNELILKTLKEITEGKTVQIPVYDFVSHSRK
EETVTVYPADVVLFEGILAFYSQEVRDLFQMKLFVDTDADTRLSRRVLRD
ISERGRDLEQILSQYITFVKPAFEEFCLPTKKYADVIIPRGADNLVAINL
IVQHIQDILNG

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6n53 Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6n53 An optimized chemical-genetic method for cell-specific metabolic labeling of RNA.
Resolution	2.7 Å
Binding residue (original residue number in PDB)	S34 E135
Binding residue (residue number reindexed from 1)	S17 E115
Annotation score	1

Enzymatic activity

Enzyme Commision number

2.7.1.48: uridine/cytidine kinase.

Gene Ontology

	Molecular Function
GO:0004849	uridine kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0042802	identical protein binding
GO:0043771	cytidine kinase activity

	Biological Process
GO:0009224	CMP biosynthetic process
GO:0016310	phosphorylation
GO:0044206	UMP salvage
GO:0044211	CTP salvage

	Cellular Component
GO:0005575	cellular_component
GO:0005737	cytoplasm
GO:0005829	cytosol

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Cellular Component

External links

PDB	RCSB:6n53, PDBe:6n53, PDBj:6n53
PDBsum	6n53
PubMed	32015544
UniProt	Q9BZX2\|UCK2_HUMAN Uridine-cytidine kinase 2 (Gene Name=UCK2)

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