Structure of PDB 6n4d Chain B Binding Site BS01

Receptor Information

>6n4d Chain B (length=388) Species: 11309 (unidentified influenza virus)

LEYRNWSKPQCQITGFAPFSKDNSIRLSAGGDIWVTREPYVSCDHSKCYQ
FALGQGTTLNNKHSNSTIHDRTSHRTLLMNELGVPFHLGTKQVCIAWSSS
SCHDGKAWLHVCVTGDDRNATASFVYNGMLVDSIGSWSRNILRTQESECV
CINGTCTVVMTDGSASGRADTRILFIREGKIIHISPLSGSAQHIEECSCY
PRYPNVRCVCRDNWKGSNRPVIDINMADYNINSSYVCSGLVGDTPRNDDS
SSSSNCKDPNNERGNPGVKGWAFDNDNDVWMGRTISKDLRSGYETFKVIG
GWTTANSKSQVNRQVIVDNNNWSGYSGIFSVEGKSCVNRCFYVELIRGGP
QETRVWWTSNSIVVFCGTSGTYGTGSWPDGANINFMPI

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6n4d Chain B Residue 501

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6n4d Assessment of Molecular, Antigenic, and Pathological Features of Canine Influenza A(H3N2) Viruses That Emerged in the United States.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): D293 G297 D324 G345 P347
• Binding residue (residue number reindexed from 1): D212 G216 D243 G264 P266
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.2.1.18: exo-alpha-sialidase.

Gene Ontology

Molecular Function

• GO:0004308 exo-alpha-sialidase activity

Biological Process

• GO:0005975 carbohydrate metabolic process
• GO:0046761 viral budding from plasma membrane

Cellular Component

• GO:0016020 membrane
• GO:0033644 host cell membrane
• GO:0055036 virion membrane

External links

• PDB: RCSB:6n4d, PDBe:6n4d, PDBj:6n4d
• PDBsum: 6n4d
• PubMed: 28934454
• UniProt: A0A0H3YBU9