Structure of PDB 6n1p Chain B Binding Site BS01

Receptor Information

>6n1p Chain B (length=481) Species: 512566 (Streptococcus pneumoniae G54) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LVNVNLTKEMKASFIDYAMSVIVARALPDVRDGLKPVHRRILYGMNELGV
TPDKPHKKSARITGDVMGKYHPHGDSSIYEAMVRMAQWWSYRYMLVDGHG
NFGSMDGDSAAAQRYTEARMSKIALEMLRDINKNTVDFVDNYDANEREPL
VLPARFPNLLVNGATGIAVGMATNIPPHNLGETIDAVKLVMDNPEVTTKD
LMEVLPGPDFPTGALVMGKSGIHKAYETGKGSIVLRSRTEIETTKTGRER
IVVTEFPYMVNKTKVHEHIVRLVQEKRIEGITAVRDESNREGVRFVIEVK
RDASANVILNNLFKMTQMQTNFGFNMLAIQNGIPKILSLRQILDAYIEHQ
KEVVVRRTRFDKEKAEARAHILEGLLIALDHIDEVIRIIRASETDAEAQA
ELMSKFKLSERQSQAILDMRLRRLTGLERDKIQSEYDDLLALIADLADIL
AKPERVSQIIKDELDEVKRKFSDKRRTELMV

Ligand information

>6n1p Chain J (length=44) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

tcgcgacgcgaggctggatggccttccccattatgattcttctc

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	6n1p CryoEM structures of open dimers of Gyrase A in complex with DNA illuminate mechanism of strand passage.
Resolution	6.35 Å
Binding residue (original residue number in PDB)	E398 T399 D400
Binding residue (residue number reindexed from 1)	E393 T394 D395

Enzymatic activity

Enzyme Commision number

5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).

Gene Ontology

	Molecular Function
GO:0003677	DNA binding
GO:0003918	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524	ATP binding

	Biological Process
GO:0006259	DNA metabolic process
GO:0006265	DNA topological change

View graph for
Molecular Function

View graph for
Biological Process

External links

PDB	RCSB:6n1p, PDBe:6n1p, PDBj:6n1p
PDBsum	6n1p
PubMed	30457554
UniProt	Q8DPM2\|GYRA_STRR6 DNA gyrase subunit A (Gene Name=gyrA)

[Back to BioLiP]