Structure of PDB 6mpb Chain B Binding Site BS01

Receptor Information
>6mpb Chain B (length=446) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DQVRRCLRANLLVLLTVVAVVAGVALGLGVSGAGGALALGPERLSAFVFP
GELLLRLLRMIILPLVVCSLIGGAASLDPGALGRLGAWALLFFLVTTLLA
SALGVGLALALQPGAASAAINASVGAAGSAENAPSKEVLDSFLDLARNIF
PSNLVSAAFRSYSTTYEERNITGTRVKVPVGQEVEGMNILGLVVFAIVFG
VALRKLGPEGELLIRFFNSFNEATMVLVSWIMWYAPVGIMFLVAGKIVEM
EDVGLLFARLGKYILCCLLGHAIHGLLVLPLIYFLFTRKNPYRFLWGIVT
PLATAFGTSSSSATLPLMMKCVEENNGVAKHISRFILPIGATVNMDGAAL
FQCVAAVFIAQLSQQSLDFVKIITILVTATASSVGAAGIPAGGVLTLAII
LEAVNLPVDHISLILAVDWLVDRSCTVLNVEGDALGAGLLQNYVDR
Ligand information
Ligand IDGLN
InChIInChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8)(H,9,10)/t3-/m0/s1
InChIKeyZDXPYRJPNDTMRX-VKHMYHEASA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(CC(=O)N)C(C(=O)O)N
OpenEye OEToolkits 1.5.0C(CC(=O)N)[C@@H](C(=O)O)N
ACDLabs 10.04O=C(N)CCC(N)C(=O)O
CACTVS 3.341N[CH](CCC(N)=O)C(O)=O
CACTVS 3.341N[C@@H](CCC(N)=O)C(O)=O
FormulaC5 H10 N2 O3
NameGLUTAMINE
ChEMBLCHEMBL930
DrugBankDB00130
ZINCZINC000001532526
PDB chain6mpb Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6mpb Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation.
Resolution3.84 Å
Binding residue
(original residue number in PDB)		S352 S353 G430 I431 G435 D464 T468
Binding residue
(residue number reindexed from 1)		S310 S311 G388 I389 G393 D422 T426
Annotation score2
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005515 protein binding
GO:0015171 amino acid transmembrane transporter activity
GO:0015175 neutral L-amino acid transmembrane transporter activity
GO:0015179 L-amino acid transmembrane transporter activity
GO:0015183 L-aspartate transmembrane transporter activity
GO:0015186 L-glutamine transmembrane transporter activity
GO:0015194 L-serine transmembrane transporter activity
GO:0015293 symporter activity
GO:0015297 antiporter activity
GO:0022834 ligand-gated channel activity
GO:0038023 signaling receptor activity
GO:0046872 metal ion binding
Biological Process
GO:0006865 amino acid transport
GO:0006868 glutamine transport
GO:0010585 glutamine secretion
GO:0015804 neutral amino acid transport
GO:0015825 L-serine transport
GO:0030218 erythrocyte differentiation
GO:0046718 symbiont entry into host cell
GO:0070207 protein homotrimerization
GO:0140009 L-aspartate import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1903803 L-glutamine import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0042470 melanosome
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mpb, PDBe:6mpb, PDBj:6mpb
PDBsum6mpb
PubMed31580259
UniProtQ15758|AAAT_HUMAN Neutral amino acid transporter B(0) (Gene Name=SLC1A5)

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