Structure of PDB 6mnl Chain B Binding Site BS01
Receptor Information
>6mnl Chain B (length=128) Species:
9606
(Homo sapiens) [
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KDVPDSQQHPAPEKSSKVSEQLKCCSGILKEMFAKKHAAYAWPFYKPVDV
EALGLHDYCDIIKHPMDMSTIKSKLEAREYRDAQEFGADVRLMFSNCYKY
NPPDHEVVAMARKLQDVFEMRFAKMPDE
Ligand information
>6mnl Chain A (length=16) Species:
9606
(Homo sapiens) [
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NPDGGKSGKAPRRRAV
Receptor-Ligand Complex Structure
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PDB
6mnl
Targeting the BRD4/FOXO3a/CDK6 axis sensitizes AKT inhibition in luminal breast cancer.
Resolution
N/A
Binding residue
(original residue number in PDB)
W374 V380 L385 L387 D389 Y390 C429 Y432 N433 H437 E438 V439
Binding residue
(residue number reindexed from 1)
W42 V48 L53 L55 D57 Y58 C97 Y100 N101 H105 E106 V107
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:6mnl
,
PDBe:6mnl
,
PDBj:6mnl
PDBsum
6mnl
PubMed
30518851
UniProt
O60885
|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)
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