Structure of PDB 6mf6 Chain B Binding Site BS01
Receptor Information
>6mf6 Chain B (length=239) Species:
559292
(Saccharomyces cerevisiae S288C) [
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QQAVLRKELIATSTNVIKSEISLRILASECHLTLNGIVEAEAQYKMGGLP
KSRLPKIKHPMIVTKWVDYSFSYQLSTEDIGVLFNNGTTVLRLADAEEFW
YISYDDREGWVASHYLLSEKPRELSRHLEVVDFFAKYMKANLHKDDVFLR
RYTRYKPFVMFELSDGTFQFNFKDHHKMAISDGGKLVTYISPSHESTTYP
LVEVLKYGEIPGYPESNFREKLTLIKEGLKQKSTIVTVD
Ligand information
>6mf6 Chain D (length=10) Species:
559292
(Saccharomyces cerevisiae S288C) [
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ARSIEGAVQV
Receptor-Ligand Complex Structure
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PDB
6mf6
Distinct surfaces on Cdc5/PLK Polo-box domain orchestrate combinatorial substrate recognition during cell division.
Resolution
3.4 Å
Binding residue
(original residue number in PDB)
W555 W565 V566 A567 H569 K610 D611 D612 F614 R616 S630
Binding residue
(residue number reindexed from 1)
W100 W110 V111 A112 H114 K144 D145 D146 F148 R150 S164
Enzymatic activity
Enzyme Commision number
2.7.11.21
: polo kinase.
External links
PDB
RCSB:6mf6
,
PDBe:6mf6
,
PDBj:6mf6
PDBsum
6mf6
PubMed
32099015
UniProt
P32562
|CDC5_YEAST Cell cycle serine/threonine-protein kinase CDC5/MSD2 (Gene Name=CDC5)
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