Structure of PDB 6mc0 Chain B Binding Site BS01

Receptor Information
>6mc0 Chain B (length=217) Species: 272624 (Legionella pneumophila subsp. pneumophila str. Philadelphia 1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HMSELKIKAAKAAIAYIEDDMVIGVGTGSTVNFFIKELAAIKHKIEACVA
SSKATEALLRAEGIPVIDLNSVQDLPIYVDGADEVNERGEMIKGGGGALT
REKIVANVATQFICIVDESKVVKRLGEFPVAVEVIPMARSFVARQIVKLG
GDPEYREGFVTDNGNIILDVFNLSFSTPMALEDSLNVIPGVVENGVFAKR
LADKVLVASASGVNNLK
Ligand information
Ligand ID5RP
InChIInChI=1S/C5H11O8P/c6-1-3(7)5(9)4(8)2-13-14(10,11)12/h4-6,8-9H,1-2H2,(H2,10,11,12)/t4-,5+/m1/s1
InChIKeyFNZLKVNUWIIPSJ-UHNVWZDZSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OCC(=O)[C@H](O)[C@H](O)CO[P](O)(O)=O
OpenEye OEToolkits 1.5.0C(C(C(C(=O)CO)O)O)OP(=O)(O)O
CACTVS 3.341OCC(=O)[CH](O)[CH](O)CO[P](O)(O)=O
ACDLabs 10.04O=P(O)(O)OCC(O)C(O)C(=O)CO
OpenEye OEToolkits 1.5.0C([C@H]([C@H](C(=O)CO)O)O)OP(=O)(O)O
FormulaC5 H11 O8 P
NameRIBULOSE-5-PHOSPHATE
ChEMBL
DrugBank
ZINCZINC000001532567
PDB chain6mc0 Chain B Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6mc0 Crystal Structure of Ribose-5-phosphate Isomerase from Legionella pneumophila with Bound Substrate Ribose-5-Phosphate and Product Ribulose-5-Phosphate
Resolution2.0 Å
Binding residue
(original residue number in PDB)		T26 S28 T29 G80 A81 D82 K92 G93 G95 A97 E101 K119
Binding residue
(residue number reindexed from 1)		T27 S29 T30 G81 A82 D83 K93 G94 G96 A98 E102 K120
Annotation score5
Enzymatic activity
Enzyme Commision number 5.3.1.6: ribose-5-phosphate isomerase.
Gene Ontology
Molecular Function
GO:0004751 ribose-5-phosphate isomerase activity
GO:0016853 isomerase activity
Biological Process
GO:0006014 D-ribose metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009052 pentose-phosphate shunt, non-oxidative branch
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6mc0, PDBe:6mc0, PDBj:6mc0
PDBsum6mc0
PubMed
UniProtQ5ZZB7|RPIA_LEGPH Ribose-5-phosphate isomerase A (Gene Name=rpiA)

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