Structure of PDB 6m63 Chain B Binding Site BS01

Receptor Information
>6m63 Chain B (length=358) Species: 6100,266835 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRGDFVRNWQLVAAVPLFQKLGPAVLVEIVRALRARTVPAGAVICRIGEP
GDRMFFVVEGSVSVATNWGNVYITADKQKNGIKANFKIRHNVEGGGVQLA
YHYQQNTPIGDGPVLLPDNHYLSVQSKLSKDPNEKRDHMVLLEFVTAAGI
TLSKGEELFTGVVPILVELDGDVNGHKFSVRGEGEGDATNGKLTLKFICT
TGKLPVPWPTLVTTLVQCFARYPDHMKQHDFFKSAMPEGYIQERTIVFKD
DGTYKTRAEVKFEGDTLVNRIELKGIDFKEDGNILGHKLEYNRVNPVELG
PGAFFGEMALISGEPRVATVSAATTVSLLSLHSADFQMLCSSSPEIAEIF
RKTALERR
Ligand information
Ligand IDCMP
InChIInChI=1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
InChIKeyIVOMOUWHDPKRLL-KQYNXXCUSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)C3C(C4C(O3)COP(=O)(O4)O)O)N
ACDLabs 10.04O=P3(OCC4OC(n1c2ncnc(N)c2nc1)C(O)C4O3)O
OpenEye OEToolkits 1.5.0c1nc(c2c(n1)n(cn2)[C@H]3[C@@H]([C@H]4[C@H](O3)CO[P@](=O)(O4)O)O)N
CACTVS 3.341Nc1ncnc2n(cnc12)[CH]3O[CH]4CO[P](O)(=O)O[CH]4[CH]3O
CACTVS 3.341Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4CO[P@](O)(=O)O[C@H]4[C@H]3O
FormulaC10 H12 N5 O6 P
NameADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE;
CYCLIC AMP;
CAMP
ChEMBLCHEMBL316966
DrugBankDB02527
ZINCZINC000003873977
PDB chain6m63 Chain B Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6m63 A high-performance genetically encoded fluorescent indicator for in vivo cAMP imaging.
Resolution2.25 Å
Binding residue
(original residue number in PDB)		V71 F330 G331 E332 M333 A334 R341 V342 A343 V345 R382
Binding residue
(residue number reindexed from 1)		V64 F305 G306 E307 M308 A309 R316 V317 A318 V320 R357
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005221 intracellularly cyclic nucleotide-activated monoatomic cation channel activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0008218 bioluminescence

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:6m63, PDBe:6m63, PDBj:6m63
PDBsum6m63
PubMed36097007
UniProtP42212|GFP_AEQVI Green fluorescent protein (Gene Name=GFP);
Q98GN8|CNGK1_RHILO Cyclic nucleotide-gated potassium channel mll3241 (Gene Name=mll3241)

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