Structure of PDB 6m27 Chain B Binding Site BS01

Receptor Information

>6m27 Chain B (length=120) Species: 243232 (Methanocaldococcus jannaschii DSM 2661) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

MEALVLVGHGSRLPYSKELLVKLAEKVKERNLFPIVEIGLMEFSEPTIPQ
AVKKAIEQGAKRIIVVPVFLAHGIHTTRDIPRLLGLIEDEIPEDVEIIYR
EPIGADDRIVDIIIDRAFGR

Ligand information

InChI=1S/Ni/q+2

VEQPNABPJHWNSG-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ni++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ni+2]

Formula

Ni

Name

NICKEL (II) ION

PDB chain

6m27 Chain B Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	6m27 The nickel-sirohydrochlorin formation mechanism of the ancestral class II chelatase CfbA in coenzyme F430 biosynthesis.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	H9 H75
Binding residue (residue number reindexed from 1)	H9 H75
Annotation score	5

Enzymatic activity

Enzyme Commision number

4.99.1.11: sirohydrochlorin nickelchelatase.
4.99.1.3: sirohydrochlorin cobaltochelatase.

Gene Ontology

	Molecular Function
GO:0016151	nickel cation binding
GO:0016829	lyase activity
GO:0016852	sirohydrochlorin cobaltochelatase activity
GO:0046872	metal ion binding
GO:0050897	cobalt ion binding

	Biological Process
GO:0009236	cobalamin biosynthetic process
GO:0015948	methanogenesis
GO:0019251	anaerobic cobalamin biosynthetic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:6m27, PDBe:6m27, PDBj:6m27
PDBsum	6m27
PubMed	34163982
UniProt	Q58380\|CFBA_METJA Sirohydrochlorin cobaltochelatase (Gene Name=cbiX)

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