Structure of PDB 6m20 Chain B Binding Site BS01

Receptor Information
>6m20 Chain B (length=478) Species: 5833 (Plasmodium falciparum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FFSTSFKYVLSACIASFIFGYQVSVLNTIKNFIVVEFEWCKGEKDRLNCS
NNTIQSSFLLASVFIGAVLGCGFSGYLVQFGRRLSLLIIYNFFFLVSILT
SITHHFHTILFARLLSGFGIGLVTVSVPMYISEMTHKDKKGAYGVMHQLF
ITFGIFVAVMLGLAMGEGPKADSTEPLTSFAKLWWRLMFLFPSVISLIGI
LALVVFFKEETPYFLFEKGRIEESKNILKKIYETDNVDEPLNAIKEAVEQ
NESAKKNSLSLLSALKIPSYRYVIILGCLLSGLQQFTGINVLVSNSNELY
KEFLDSHLITILSVVMTAVNFLMTFPAIYIVEKLGRKTLLLWGCVGVLVA
YLPTAIANEINRNSNFVKILSIVATFVMIISFAVSYGPVLWIYLHEMFPS
EIKDSAASLASLVNWVCAIIVVFPSDIIIKKSPSILFIVFSVMSILTFFF
IFFFIKETKGGEIGTSPYITMEERQKHM
Ligand information
Ligand IDBGC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6-/m1/s1
InChIKeyWQZGKKKJIJFFOK-VFUOTHLCSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.370OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O
CACTVS 3.370OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
OpenEye OEToolkits 1.7.6C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)O)O)O)O
ACDLabs 12.01OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namebeta-D-glucopyranose;
beta-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL1614854
DrugBankDB02379
ZINCZINC000003833800
PDB chain6m20 Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6m20 Structural Basis for Blocking Sugar Uptake into the Malaria Parasite Plasmodium falciparum.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		Q169 Q305 N311 G408 W412
Binding residue
(residue number reindexed from 1)		Q148 Q284 N290 G387 W391
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0015149 hexose transmembrane transporter activity
GO:0022857 transmembrane transporter activity
Biological Process
GO:0008645 hexose transmembrane transport
GO:0015749 monosaccharide transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6m20, PDBe:6m20, PDBj:6m20
PDBsum6m20
PubMed32860739
UniProtO97467

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