BioLiP

InChI=1S/C19H27N3O4/c1-11(2)16(23)18(25)20-12(3)17(24)21-15-14-8-6-5-7-13(14)9-10-22(4)19(15)26/h5-8,11-12,15-16,23H,9-10H2,1-4H3,(H,20,25)(H,21,24)/t12-,15-,16-/m0/s1

InChIKey

PKXWXXPNHIWQHW-RCBQFDQVSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 2.0.7	C[C@@H](C(=O)NC1c2ccccc2CCN(C1=O)C)NC(=O)[C@H](C(C)C)O
CACTVS 3.385	CC(C)[C@H](O)C(=O)N[C@@H](C)C(=O)N[C@@H]1C(=O)N(C)CCc2ccccc12
OpenEye OEToolkits 2.0.7	CC(C)C(C(=O)NC(C)C(=O)NC1c2ccccc2CCN(C1=O)C)O
CACTVS 3.385	CC(C)[CH](O)C(=O)N[CH](C)C(=O)N[CH]1C(=O)N(C)CCc2ccccc12

Formula

C19 H27 N3 O4

Name

(2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide

PDB chain

6lr4 Chain B Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Molecular Function

GO:0004175

endopeptidase activity

GO:0004190

aspartic-type endopeptidase activity

GO:0005262

calcium channel activity

protein binding

beta-catenin binding

peptidase activity

PDZ domain binding

aspartic endopeptidase activity, intramembrane cleaving

GO:0045296

cadherin binding

GO:0051117

ATPase binding

GO:0070851

growth factor receptor binding

	Biological Process
GO:0000045	autophagosome assembly
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0001568	blood vessel development
GO:0001708	cell fate specification
GO:0001756	somitogenesis
GO:0001764	neuron migration
GO:0001921	positive regulation of receptor recycling
GO:0001947	heart looping
GO:0002038	positive regulation of L-glutamate import across plasma membrane
GO:0002244	hematopoietic progenitor cell differentiation
GO:0002265	astrocyte activation involved in immune response
GO:0002286	T cell activation involved in immune response
GO:0002573	myeloid leukocyte differentiation
GO:0003407	neural retina development
GO:0006486	protein glycosylation
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0006839	mitochondrial transport
GO:0006874	intracellular calcium ion homeostasis
GO:0006914	autophagy
GO:0006915	apoptotic process
GO:0006974	DNA damage response
GO:0006979	response to oxidative stress
GO:0007155	cell adhesion
GO:0007175	negative regulation of epidermal growth factor-activated receptor activity
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007420	brain development
GO:0007507	heart development
GO:0007611	learning or memory
GO:0007613	memory
GO:0009791	post-embryonic development
GO:0010467	gene expression
GO:0010468	regulation of gene expression
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0010975	regulation of neuron projection development
GO:0015031	protein transport
GO:0015871	choline transport
GO:0016080	synaptic vesicle targeting
GO:0016485	protein processing
GO:0021549	cerebellum development
GO:0021795	cerebral cortex cell migration
GO:0021870	Cajal-Retzius cell differentiation
GO:0021904	dorsal/ventral neural tube patterning
GO:0021987	cerebral cortex development
GO:0022008	neurogenesis
GO:0030182	neuron differentiation
GO:0030326	embryonic limb morphogenesis
GO:0030900	forebrain development
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032469	endoplasmic reticulum calcium ion homeostasis
GO:0032760	positive regulation of tumor necrosis factor production
GO:0034205	amyloid-beta formation
GO:0035282	segmentation
GO:0035556	intracellular signal transduction
GO:0040011	locomotion
GO:0042307	positive regulation of protein import into nucleus
GO:0042325	regulation of phosphorylation
GO:0042982	amyloid precursor protein metabolic process
GO:0042987	amyloid precursor protein catabolic process
GO:0043011	myeloid dendritic cell differentiation
GO:0043065	positive regulation of apoptotic process
GO:0043066	negative regulation of apoptotic process
GO:0043524	negative regulation of neuron apoptotic process
GO:0043589	skin morphogenesis
GO:0045821	positive regulation of glycolytic process
GO:0045893	positive regulation of DNA-templated transcription
GO:0048143	astrocyte activation
GO:0048167	regulation of synaptic plasticity
GO:0048538	thymus development
GO:0048666	neuron development
GO:0048705	skeletal system morphogenesis
GO:0048854	brain morphogenesis
GO:0050435	amyloid-beta metabolic process
GO:0050673	epithelial cell proliferation
GO:0050771	negative regulation of axonogenesis
GO:0050808	synapse organization
GO:0050820	positive regulation of coagulation
GO:0050852	T cell receptor signaling pathway
GO:0051208	sequestering of calcium ion
GO:0051402	neuron apoptotic process
GO:0051444	negative regulation of ubiquitin-protein transferase activity
GO:0051563	smooth endoplasmic reticulum calcium ion homeostasis
GO:0051604	protein maturation
GO:0051966	regulation of synaptic transmission, glutamatergic
GO:0055074	calcium ion homeostasis
GO:0060075	regulation of resting membrane potential
GO:0060828	regulation of canonical Wnt signaling pathway
GO:0060999	positive regulation of dendritic spine development
GO:0070050	neuron cellular homeostasis
GO:0070588	calcium ion transmembrane transport
GO:0097190	apoptotic signaling pathway
GO:0098609	cell-cell adhesion
GO:0098693	regulation of synaptic vesicle cycle
GO:0098712	L-glutamate import across plasma membrane
GO:0099175	regulation of postsynapse organization
GO:0140249	protein catabolic process at postsynapse
GO:1904646	cellular response to amyloid-beta
GO:1904797	negative regulation of core promoter binding
GO:1905598	negative regulation of low-density lipoprotein receptor activity
GO:1905908	positive regulation of amyloid fibril formation
GO:1990535	neuron projection maintenance
GO:2000059	negative regulation of ubiquitin-dependent protein catabolic process
GO:2001234	negative regulation of apoptotic signaling pathway

Biological Process

GO:0000045

autophagosome assembly

GO:0000122

negative regulation of transcription by RNA polymerase II

GO:0001568

blood vessel development

GO:0001708

cell fate specification

GO:0001756

somitogenesis

GO:0001764

neuron migration

GO:0001921

positive regulation of receptor recycling

GO:0001947

heart looping

GO:0002038

positive regulation of L-glutamate import across plasma membrane

GO:0002244

hematopoietic progenitor cell differentiation

GO:0002265

astrocyte activation involved in immune response

GO:0002286

T cell activation involved in immune response

GO:0002573

myeloid leukocyte differentiation

GO:0003407

neural retina development

GO:0006486

protein glycosylation

GO:0006508

proteolysis

GO:0006509

membrane protein ectodomain proteolysis

GO:0006839

mitochondrial transport

GO:0006874

intracellular calcium ion homeostasis

autophagy

apoptotic process

DNA damage response

response to oxidative stress

GO:0007155

cell adhesion

GO:0007175

negative regulation of epidermal growth factor-activated receptor activity

GO:0007219

Notch signaling pathway

GO:0007220

Notch receptor processing

brain development

heart development

learning or memory

memory

post-embryonic development

GO:0010467

gene expression

GO:0010468

regulation of gene expression

GO:0010628

positive regulation of gene expression

GO:0010629

negative regulation of gene expression

GO:0010975

regulation of neuron projection development

GO:0015031

protein transport

GO:0015871

choline transport

GO:0016080

synaptic vesicle targeting

GO:0016485

protein processing

GO:0021549

cerebellum development

GO:0021795

cerebral cortex cell migration

GO:0021870

Cajal-Retzius cell differentiation

GO:0021904

dorsal/ventral neural tube patterning

GO:0021987

cerebral cortex development

GO:0022008

neurogenesis

GO:0030182

neuron differentiation

GO:0030326

embryonic limb morphogenesis

GO:0030900

forebrain development

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

GO:0032469

endoplasmic reticulum calcium ion homeostasis

GO:0032760

positive regulation of tumor necrosis factor production

GO:0034205

amyloid-beta formation

GO:0035282

segmentation

GO:0035556

intracellular signal transduction

GO:0040011

locomotion

GO:0042307

positive regulation of protein import into nucleus

GO:0042325

regulation of phosphorylation

GO:0042982

amyloid precursor protein metabolic process

GO:0042987

amyloid precursor protein catabolic process

GO:0043011

myeloid dendritic cell differentiation

GO:0043065

positive regulation of apoptotic process

GO:0043066

negative regulation of apoptotic process

GO:0043524

negative regulation of neuron apoptotic process

GO:0043589

skin morphogenesis

GO:0045821

positive regulation of glycolytic process

GO:0045893

positive regulation of DNA-templated transcription

GO:0048143

astrocyte activation

GO:0048167

regulation of synaptic plasticity

GO:0048538

thymus development

GO:0048666

neuron development

GO:0048705

skeletal system morphogenesis

GO:0048854

brain morphogenesis

GO:0050435

amyloid-beta metabolic process

GO:0050673

epithelial cell proliferation

GO:0050771

negative regulation of axonogenesis

GO:0050808

synapse organization

GO:0050820

positive regulation of coagulation

GO:0050852

T cell receptor signaling pathway

GO:0051208

sequestering of calcium ion

GO:0051402

neuron apoptotic process

GO:0051444

negative regulation of ubiquitin-protein transferase activity

GO:0051563

smooth endoplasmic reticulum calcium ion homeostasis

GO:0051604

protein maturation

GO:0051966

regulation of synaptic transmission, glutamatergic

GO:0055074

calcium ion homeostasis

GO:0060075

regulation of resting membrane potential

GO:0060828

regulation of canonical Wnt signaling pathway

GO:0060999

positive regulation of dendritic spine development

GO:0070050

neuron cellular homeostasis

GO:0070588

calcium ion transmembrane transport

GO:0097190

apoptotic signaling pathway

GO:0098609

cell-cell adhesion

GO:0098693

regulation of synaptic vesicle cycle

GO:0098712

L-glutamate import across plasma membrane

GO:0099175

regulation of postsynapse organization

GO:0140249

protein catabolic process at postsynapse

GO:1904646

cellular response to amyloid-beta

GO:1904797

negative regulation of core promoter binding

GO:1905598

negative regulation of low-density lipoprotein receptor activity

GO:1905908

positive regulation of amyloid fibril formation

GO:1990535

neuron projection maintenance

GO:2000059

negative regulation of ubiquitin-dependent protein catabolic process

GO:2001234

negative regulation of apoptotic signaling pathway

	Cellular Component
GO:0000139	Golgi membrane
GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005640	nuclear outer membrane
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005765	lysosomal membrane
GO:0005768	endosome
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005790	smooth endoplasmic reticulum
GO:0005791	rough endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005938	cell cortex
GO:0008021	synaptic vesicle
GO:0009986	cell surface
GO:0016020	membrane
GO:0016235	aggresome
GO:0030054	cell junction
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031410	cytoplasmic vesicle
GO:0031594	neuromuscular junction
GO:0031901	early endosome membrane
GO:0031965	nuclear membrane
GO:0032991	protein-containing complex
GO:0035253	ciliary rootlet
GO:0035577	azurophil granule membrane
GO:0042383	sarcolemma
GO:0042734	presynaptic membrane
GO:0042995	cell projection
GO:0043005	neuron projection
GO:0043025	neuronal cell body
GO:0043198	dendritic shaft
GO:0045121	membrane raft
GO:0045202	synapse
GO:0070765	gamma-secretase complex
GO:0097060	synaptic membrane
GO:0098794	postsynapse
GO:0098978	glutamatergic synapse

Cellular Component

Golgi membrane

kinetochore

nucleus

nuclear outer membrane

GO:0005654

nucleoplasm

GO:0005737