Structure of PDB 6l6r Chain B Binding Site BS01

Receptor Information

>6l6r Chain B (length=610) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

DPLLLYANRRDLRLVDATNENATIVVGGLEDAAAVDFVFSHGLIYWSDVS
EEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEV
SNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGS
SRFIIINSEIYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVK
GSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMDI
HAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGK
TCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVE
GYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTD
TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKI
ERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDG
TGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRSAEREVIIDQ
LPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLRCACPIGFELI
SDMKTCIVPH

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

6l6r Chain B Residue 1007 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6l6r Sclerostin inhibits Wnt signaling through tandem interaction with two LRP6 ectodomains.
Resolution	3.8 Å
Binding residue (original residue number in PDB)	S114 N117 D138 Q139
Binding residue (residue number reindexed from 1)	S93 N96 D117 Q118
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:6l6r, PDBe:6l6r, PDBj:6l6r
PDBsum	6l6r
PubMed	33097721
UniProt	O75581\|LRP6_HUMAN Low-density lipoprotein receptor-related protein 6 (Gene Name=LRP6)

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