Structure of PDB 6kur Chain B Binding Site BS01

Receptor Information

>6kur Chain B (length=705) Species: 1173138 (Influenza D virus (D/swine/Oklahoma/1334/2011))

MEINPYLLMLNNDITSMISLTYPYTGAPPMSHGTSTKYSMETVSRTYSYS
RTKKEVPSGIFPIERRKFCNTIEDKENLEKPNGNVDINFMLSLAEMLEEK
MGKGFFKFCANEAEAEILKMHFSKLTEGRQTYDWTSERNMPAATALQLTV
DAIQETQGTFKGTTMVEYCNKILEMMDWPEVKFKKVTLMITKIGREEFIK
RICTINTMAKDGERGKYKRRAIATPGMGIRPFSKIVETLAQKICERLAES
GLPVEKKAKLKTTVSSTNSKLQEGQFMVNITGDNSKWNECQQPEAYLAML
AYITKDSSNLMKDLCSVAPTLFCNKYVKMGQGFRAKNKRKTKEIVIPAKK
MKERKELMNAEWRDLFETIEPYMDGECCFLGGGMLMGMFNMLSTVFGVMT
LNYREERNCYWTGLQSSDDFVLFCISRTWPEMEMTILKFIAVCKLMGINM
SLEKSYGCLPELFEFTSMFFSGDFVSNIALELPAFTTAGMNEGTDFTAAM
SVIRTNMINNGLSPGTALMALRICLQEFRATYRVHPYDSGVKNHRMKIIR
KFIETIENKDGLLISDGGKLMNNISSLHIPEEILKEDLMDPSYRNRVFNP
RNPFTQFAVVSTHSFRTRSNRTLLNTDMRAMALEEKRYQVVCNMYRSVFE
SADVNTPIGSMSMGEAIEAKILDRARTQFENGIIGGEEYSEIKRLIEDAK
RQRLS

Ligand information

>6kur Chain R (length=13)

cuccugcuuaugc

.............

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6kur Structural insight into RNA synthesis by influenza D polymerase.
• Resolution: 3.7 Å
• Binding residue (original residue number in PDB): Q554 A558 R561 N571 H572
• Binding residue (residue number reindexed from 1): Q526 A530 R533 N543 H544

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0034062 5'-3' RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:6kur, PDBe:6kur, PDBj:6kur
• PDBsum: 6kur
• PubMed: 31209309
• UniProt: K9LH03