Structure of PDB 6kuk Chain B Binding Site BS01

Receptor Information

>6kuk Chain B (length=701) Species: 1173138 (Influenza D virus (D/swine/Oklahoma/1334/2011))

MEINPYLLMLNNDITSMISLTYPYTGAPPMSHGTSTKYSMETVSRTYSYS
RTKKEVPSGIFPIERRKFCNTIEDKENLEKPNGNVDINFMLSLAEMLEEK
MGKGFFKFCANEAEAEILKMHFSKLTEGRQTYDWTSERNMPAATALQLTV
DAIQETQGTFKGTTMVEYCNKILEMMDWPEVKFKKVTLMITKIGREEFIK
RICTINTMAKDGERGKYKRRAIATPGMGIRPFSKIVETLAQKICERLAES
GKKAKLKTTVSSTNSKLQEGQFMVNITGDNSKWNECQQPEAYLAMLAYIT
KDSSNLMKDLCSVAPTLFCNKYVKMGQGFRAKNKRKTKEIVIPAKKMKER
KELMNAEWRDLFETIEPYMDGECCFLGGGMLMGMFNMLSTVFGVMTLNYR
EERNCYWTGLQSSDDFVLFCISRTWPEMEMTILKFIAVCKLMGINMSLEK
SYGCLPELFEFTSMFFSGDFVSNIALELPAFTTAGMNEGTDFTAAMSVIR
TNMINNGLSPGTALMALRICLQEFRATYRVHPYDSGVKNHRMKIIRKFIE
TIENKDGLLISDGGKLMNNISSLHIPEEILKEDLMDPSYRNRVFNPRNPF
TQFAVVSTHSFRTRSNRTLLNTDMRAMALEEKRYQVVCNMYRSVFESADV
NTPIGSMSMGEAIEAKILDRARTQFENGIIGGEEYSEIKRLIEDAKRQRL
S

Ligand information

>6kuk Chain R (length=8)

cuccugcu

........

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6kuk Structural insight into RNA synthesis by influenza D polymerase.
• Resolution: 3.9 Å
• Binding residue (original residue number in PDB): R138 R668 T669 N672
• Binding residue (residue number reindexed from 1): R138 R617 T618 N621

Enzymatic activity

• Enzyme Commision number: 2.7.7.48: RNA-directed RNA polymerase.

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0003723 RNA binding
• GO:0003968 RNA-dependent RNA polymerase activity
• GO:0034062 5'-3' RNA polymerase activity

Biological Process

• GO:0001172 RNA-templated transcription
• GO:0006351 DNA-templated transcription
• GO:0019079 viral genome replication
• GO:0039694 viral RNA genome replication

External links

• PDB: RCSB:6kuk, PDBe:6kuk, PDBj:6kuk
• PDBsum: 6kuk
• PubMed: 31209309
• UniProt: K9LH03