Structure of PDB 6ksy Chain B Binding Site BS01

Receptor Information

>6ksy Chain B (length=289) Species: 264203 (Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821)

SSINKPLRLIFPQWQGGDNPPYYLGSQLLAWLSPDPKGAVEEVPVPKPTG
EPLQEENGIVGRSILIDQLSEARQLIEKHTPDSLVVLGGDCLVSLAPFSW
LLEKYKDKLGILWIDSHPDVQTPKEYKNAHAHVLGELMGNGDSDFTRTVK
HPVSPQKIMIAGIHDPLPYEANFISEHKIQTCSPEQVRSGAQPVLDWIKN
EKIEYLAIHIDLDVLDPHNFRSVLFAKPGRGQHDFGDVAEGKLNIPDVVK
LANQAASISKAVGLTIAEHLPWDALNLKNMLEELPLIGK

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 6ksy Chain B Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ksy Characterization of a Dimeric Arginase FromZymomonas mobilisZM4.
• Resolution: 1.649 Å
• Binding residue (original residue number in PDB): D116 H118 D212 D214
• Binding residue (residue number reindexed from 1): D115 H117 D211 D213
• Annotation score: 1

Gene Ontology

Molecular Function

• GO:0004053 arginase activity
• GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding

Biological Process

• GO:0019547 arginine catabolic process to ornithine

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:6ksy, PDBe:6ksy, PDBj:6ksy
• PDBsum: 6ksy
• PubMed: 32038508
• UniProt: Q5NQE9