Structure of PDB 6knm Chain B Binding Site BS01

Receptor Information
>6knm Chain B (length=351) Species: 1501,9606 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIF
IASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASA
FCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVL
RTTGDLENTNKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIM
LTCYFFIAQTIAMKKYTCTVCGYIYNPEDGDPDNGVNPGTDFKDIPDDWV
CPLCGVGKDQFEEVEERRRLLSIIVVLVVTFALCKMPYHLVKTLYMLGSL
LHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLLM
G
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6knm Chain B Residue 1101 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6knm Structure-guided discovery of a single-domain antibody agonist against human apelin receptor.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		C1006 C1009 C1039
Binding residue
(residue number reindexed from 1)		C218 C221 C251
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0005506 iron ion binding
GO:0009055 electron transfer activity
GO:0046872 metal ion binding
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
GO:0043448 alkane catabolic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6knm, PDBe:6knm, PDBj:6knm
PDBsum6knm
PubMed31998837
UniProtP00268|RUBR_CLOPA Rubredoxin;
P35414|APJ_HUMAN Apelin receptor (Gene Name=APLNR)

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