Structure of PDB 6kho Chain B Binding Site BS01

Receptor Information
>6kho Chain B (length=475) Species: 39947 (Oryza sativa Japonica Group) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TFQPLNADDVRSYLHKAVDFISDYYKSVESMPVLPNVKPGYLQDELRASP
PTYSAPFDVTMKELRSSVVPGMTHWASPNFFAFFPSTNSAAAIAGDLIAS
AMNTVGFTWQASPAATEMEVLALDWLAQMLNLPTSFMNRTGEGRGTGGGV
ILGTTSEAMLVTLVAARDAALRRSGSDGVAGLHRLAVYAADQTHSTFFKA
CRLAGFDPANIRSIPTGAETDYGLDPARLLEAMQADADAGLVPTYVCATV
GTTSSNAVDPVGAVADVAARFAAWVHVDAAYAGSACICPEFRHHLDGVER
VDSISMSPHKWLMTCLDCTCLYVRDTHRLEVTDLKDMQVGVGRRFRGLKL
WMVMRTYGVAKLQEHIRSDVAMAKVFEDLVRGDDRFEVVVPRNFALVCFR
IRAGAGAAAATEEDADEANRELMERLNKTGKAYVAHTVVGGRFVLRFAVG
SSLQEEHHVRSAWELIKKTTTEMMN
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain6kho Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6kho Crystal structure ofOryza sativaTDC reveals the substrate specificity for TDC-mediated melatonin biosynthesis.
Resolution1.972 Å
Binding residue
(original residue number in PDB)		V380 G381
Binding residue
(residue number reindexed from 1)		V341 G342
Annotation score1
Enzymatic activity
Enzyme Commision number 4.1.1.28: aromatic-L-amino-acid decarboxylase.
Gene Ontology
Molecular Function
GO:0016830 carbon-carbon lyase activity
GO:0016831 carboxy-lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0036467 5-hydroxy-L-tryptophan decarboxylase activity
GO:0036469 L-tryptophan decarboxylase activity
Biological Process
GO:0006520 amino acid metabolic process
GO:0006587 serotonin biosynthetic process from tryptophan
GO:0019752 carboxylic acid metabolic process
GO:0042427 serotonin biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6kho, PDBe:6kho, PDBj:6kho
PDBsum6kho
PubMed32595985
UniProtQ6ZJK7|TDC1_ORYSJ Tryptophan decarboxylase 1 (Gene Name=TDC1)

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