Structure of PDB 6k5h Chain B Binding Site BS01

Receptor Information
>6k5h Chain B (length=286) Species: 763924 (Phytophthora capsici LT1534) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
THSDGTVLHLGLRAGQVANRIVSVGSLGRAKVLAQLLDEGHFETFESARG
FTTYSGKVKGVPVSIVATGMGVPNMDFVVRETRAVVNGPMTIIRFGTCGA
VREEVPPGSVVVNGKGSIMVTRNPDAFFPGASEEDCYRVSRVMPSSSTLS
KALVASMEDKLTALRAEPVIAASSDCDALRVFDGLNATACSFYSSQGRLD
SNFDDRNEKLVEDLTTAHPDLYTVEMETFHLLDLAQRSRGSIQATAAVLV
VANRLSGQIVESEVLEALESFWGGVVLQTIVSTPLD
Ligand information
Ligand IDURA
InChIInChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
InChIKeyISAKRJDGNUQOIC-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341O=C1NC=CC(=O)N1
ACDLabs 10.04O=C1C=CNC(=O)N1
OpenEye OEToolkits 1.5.0C1=CNC(=O)NC1=O
FormulaC4 H4 N2 O2
NameURACIL
ChEMBLCHEMBL566
DrugBankDB03419
ZINCZINC000000895045
PDB chain6k5h Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6k5h Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici.
Resolution2.503 Å
Binding residue
(original residue number in PDB)		C108 G109 F202 Q206 R208 E235
Binding residue
(residue number reindexed from 1)		C98 G99 F192 Q196 R198 E225
Annotation score5
Enzymatic activity
Enzyme Commision number 2.4.2.3: uridine phosphorylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004850 uridine phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047847 deoxyuridine phosphorylase activity
Biological Process
GO:0006218 uridine catabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6k5h, PDBe:6k5h, PDBj:6k5h
PDBsum6k5h
PubMed32493959
UniProtA0A410UCT3

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