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BioLiP

Structure of PDB 6k1h Chain B Binding Site BS01

Receptor Information
>6k1h Chain B (length=247) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
EITTLQIVLVFIVACIAGMGSILDEFQFHRPLIACTLVGIVLGDMKTGII
IGGTLEMIALGWMNIGAAVAPDAALASIISTILVIAGHQSIGAGIALAIP
LAAAGQVLTIIVRTITVAFQHAADKAADNGNLTAISWIHVSSLFLQAMRV
AIPAVIVALSVGTSEVQNMLNAIPEVVTNGLNIAGGMIVVVGYAMVINMM
RAGYLMPFFYLGFVTAAFTNFNLVALGVIGTVMAVLYIQLSPKYNRV
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain6k1h Chain C Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6k1h Structure of the mannose transporter of the bacterial phosphotransferase system.
Resolution3.52 Å
Binding residue
(original residue number in PDB)		N65 G67
Binding residue
(residue number reindexed from 1)		N64 G66
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0022870 protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
Biological Process
GO:0009401 phosphoenolpyruvate-dependent sugar phosphotransferase system
GO:0015761 mannose transmembrane transport
GO:0015764 N-acetylglucosamine transport
GO:0098708 D-glucose import across plasma membrane
GO:1990539 fructose import across plasma membrane
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:1902495 transmembrane transporter complex

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Cellular Component
External links
PDB RCSB:6k1h, PDBe:6k1h, PDBj:6k1h
PDBsum6k1h
PubMed31209249
UniProtP69801|PTNC_ECOLI PTS system mannose-specific EIIC component (Gene Name=manY)

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