Structure of PDB 6k18 Chain B Binding Site BS01

Receptor Information
>6k18 Chain B (length=196) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVVTVSQEAEWDQIEPLLRSELEDFPVLGIDCEWVNLSPLSLLQMASPSG
LCVLVRLPKLICGGKTLPRTLLDILADGTILKVGVGCSEDASKLLQDYGL
VVRGCLDLRYLAMRQRNNLLCNGLSLKSLAETVLNFPLDLLLRCSNWDAE
TLTEDQVIYAARDAQISVALFLHLLGYPSWRKVLEKCQGVVDIPFR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain6k18 Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6k18 The structure of human EXD2 reveals a chimeric 3' to 5' exonuclease domain that discriminates substrates via metal coordination.
Resolution2.303 Å
Binding residue
(original residue number in PDB)		D108 E110
Binding residue
(residue number reindexed from 1)		D31 E33
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.11.1: exodeoxyribonuclease I.
3.1.13.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:6k18, PDBe:6k18, PDBj:6k18
PDBsum6k18
PubMed31127291
UniProtQ9NVH0|EXD2_HUMAN Exonuclease 3'-5' domain-containing protein 2 (Gene Name=EXD2)

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