Structure of PDB 6j7f Chain B Binding Site BS01

Receptor Information
>6j7f Chain B (length=329) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TPQKDVIIKSDAPDTLLLEKHADYIASYGSKKDDYEYCMSEYLRMSGIYW
GLTVMDLMGQLHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAV
QILTLYDSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVAT
LALLGKLDAINVEKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLA
ITSQLHQVNSDLLGWWLCERQLPSGGLNGRPEKLPDVCYSWWVLASLKII
GRLHWIDREKLRNFILACQDEETGGFADRPGDMVDPFHTLFGIAGLSLLG
EEQIKPVNPVFCMPEEVLQRVNVQPELVS
Ligand information
Ligand IDFAR
InChIInChI=1S/C15H26/c1-6-14(4)10-8-12-15(5)11-7-9-13(2)3/h6,9,12H,7-8,10-11H2,1-5H3/b14-6+,15-12+
InChIKeyJXBSHSBNOVLGHF-BUJBXKITSA-N
SMILES
SoftwareSMILES
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CC=C(C)CCC=C(C)CCC=C(C)C
OpenEye OEToolkits 1.5.0C\C=C(/C)\CC\C=C(/C)\CCC=C(C)C
CACTVS 3.341C\C=C(C)\CC\C=C(C)\CCC=C(C)C
ACDLabs 10.04C(=C/C)(\CC/C=C(/CC/C=C(\C)C)C)C
FormulaC15 H26
NameFARNESYL
ChEMBL
DrugBank
ZINC
PDB chain6j7f Chain B Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6j7f Complex of GGTaseIII, farnesyl-Ykt6 (C-terminal methylated), and GGPP
Resolution2.883 Å
Binding residue
(original residue number in PDB)		Y30 G49 I50 W52 F289
Binding residue
(residue number reindexed from 1)		Y28 G47 I48 W50 F287
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.60: protein geranylgeranyltransferase type II.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004659 prenyltransferase activity
GO:0004661 protein geranylgeranyltransferase activity
GO:0004663 Rab geranylgeranyltransferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0008318 protein prenyltransferase activity
GO:0031267 small GTPase binding
GO:0046872 metal ion binding
Biological Process
GO:0007601 visual perception
GO:0018344 protein geranylgeranylation
GO:0036211 protein modification process
Cellular Component
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005968 Rab-protein geranylgeranyltransferase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6j7f, PDBe:6j7f, PDBj:6j7f
PDBsum6j7f
PubMed
UniProtP53611|PGTB2_HUMAN Geranylgeranyl transferase type-2 subunit beta (Gene Name=RABGGTB)

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