Structure of PDB 6iso Chain B Binding Site BS01

Receptor Information
>6iso Chain B (length=264) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSQYDLPYPEAIFE
LPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNID
GLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCP
VCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLT
EAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTE
EMRDLVQRETGKLA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6iso Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.
Resolution2.95 Å
Binding residue
(original residue number in PDB)		H248 V292 F293 F294 G295 E296 E323 V324 E325
Binding residue
(residue number reindexed from 1)		H117 V161 F162 F163 G164 E165 E192 V193 E194
Enzymatic activity
Catalytic site (original residue number in PDB) P155 D156 F157 R158 N229 D231 H248
Catalytic site (residue number reindexed from 1) P34 D35 F36 R37 N98 D100 H117
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:6iso, PDBe:6iso, PDBj:6iso
PDBsum6iso
PubMed25369635
UniProtQ9NTG7|SIR3_HUMAN NAD-dependent protein deacetylase sirtuin-3, mitochondrial (Gene Name=SIRT3)

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