Structure of PDB 6imn Chain B Binding Site BS01

Receptor Information

>6imn Chain B (length=408) Species: 10497 (African swine fever virus)

LNQFPGQYSNNIFCFPPIESETKSGKKASWIICVQVVQHNTIIPITDEMF
STDVKDAVAEIFTKFFVEEGAVRISKMTRVTEGKNLGKKNATTVVHQAFK
DALSKYNRHARQKRGGMIPPMLVKYFNIIPKTFFEEETDPIVQRKRNGVR
AVACQQGDGCILLYSRTEKEFLGLDNIKKELKQLYLFIDVRVYLDGELYL
HRKPLQWIAGQANAKTDSSELHFYVFDCFWSDQLQMPSNKRQQLLTNIFK
QKEDLTFIHQVENFSVKNVDEALRLKAQFIKEGYEGAIVRNANGPYEPGY
NNYHSAHLAKLKPLLDAEFILVDYTQGKKGKDLGAILWVCELPNKKRFVV
TPKHLTYADRYALFQKLTPALFKKHLYGKELTVEYAELSPKTGIPLQARA
VGFREPIN

Ligand information

>6imn Chain C (length=22)

ccagtccgacccgcatcccgga

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6imn Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): K24 W31 K90 N91 K114 Q212 G216 A220 N307 Y309 K335 K337 F354 V355 S395 K397 T398
• Binding residue (residue number reindexed from 1): K23 W30 K89 N90 K113 Q206 G210 A214 N301 Y303 K329 K331 F348 V349 S389 K391 T392

Enzymatic activity

• Enzyme Commision number: 6.5.1.1: DNA ligase (ATP).

Gene Ontology

Molecular Function

• GO:0003909 DNA ligase activity
• GO:0003910 DNA ligase (ATP) activity
• GO:0005524 ATP binding
• GO:0016874 ligase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006281 DNA repair
• GO:0006310 DNA recombination
• GO:0051301 cell division

Cellular Component

• GO:0044423 virion component

External links

• PDB: RCSB:6imn, PDBe:6imn, PDBj:6imn
• PDBsum: 6imn
• PubMed: 30674878
• UniProt: P35970|DNLI_ASFB7 DNA ligase (Gene Name=LIG)