Structure of PDB 6ig4 Chain B Binding Site BS01

Receptor Information

>6ig4 Chain B (length=272) Species: 284812 (Schizosaccharomyces pombe 972h-)

CTVAQLLKQNLLTFENQRIQPEEELKENLTKVVNYFQAPIDVAVGYGSGV
FRQNPMIDFIFQVEDPVKWHKINLQQNPSHYSFVKNVSTLQESFGTGVYY
NTHVEVEGNIIKYGVTSKKDVYEDLKNWNTMYLAGRFQKPVVILKGEDEF
YKENSYNLSSALHVGLLMLADRFTEFDLYKTIVSLSYLGDIRMSFFAENP
RKVENIVSKQIAFFRKLYLPLLYAEPGVHFIESSEVLKSMDPSDNSRYLS
FHQNITKDSISRLLNGLPLNLV

Ligand information

• Ligand ID: 3G0
• InChI: InChI=1S/4CN.Pt/c4*1-2;/q;;;;-2
• InChIKey: YGIVBGPIGPIOSX-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.385: N#C[Pt--](C#N)(C#N)C#N
  OpenEye OEToolkits 1.7.6: C(#N)[Pt-2](C#N)(C#N)C#N
  ACDLabs 12.01: N#C[Pt-2](C#N)(C#N)C#N
• Formula: C4 N4 Pt
• Name: tetracyanoplatinate(II);
  [Pt(CN)4]2-
• PDB chain: 6ig4 Chain B Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6ig4 Structures of the Mitochondrial CDP-DAG Synthase Tam41 Suggest a Potential Lipid Substrate Pathway from Membrane to the Active Site.
• Resolution: 2.261 Å
• Binding residue (original residue number in PDB): G79 S80 R245 I250 K253
• Binding residue (residue number reindexed from 1): G47 S48 R201 I206 K209
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.7.7.41: phosphatidate cytidylyltransferase.

Gene Ontology

Molecular Function

• GO:0004605 phosphatidate cytidylyltransferase activity

Biological Process

• GO:0032049 cardiolipin biosynthetic process

External links

• PDB: RCSB:6ig4, PDBe:6ig4, PDBj:6ig4
• PDBsum: 6ig4
• PubMed: 31178220
• UniProt: O74339|TAM41_SCHPO Phosphatidate cytidylyltransferase, mitochondrial (Gene Name=tam41)